The case studies presented here provide evidence for the presence of D-MER. Research is needed to better understand its pathophysiology, incidence, and treatment options.
chart review was performed in cases of borderline proteinuria (250-400 mg) to document preeclampsia criteria.RESULTS: EMR search identified 3,869 records. Analytical cohort included 987 subjects after application of exclusionary criteria and elimination of multiple results. Of women with 24-hour urine protein measurements, those with normal BMIs (n5409; 3856647 mg/day) did not have a significant difference in mean proteinuria measurement compared to those with obese BMIs (n5399; 3766541 mg/day) (P5.30). Of women with a urine protein:creatinine, those with normal BMI (n569, 5356956 mg/g) had significantly increased proteinuria compared to obese women (n571; 3806956 mg/g, P5.03). Of the 199 women with borderline proteinuria, 59 (29.6%) met criteria for preeclampsia by both blood pressures and proteinuria and 20 (10.1%) also had symptoms such as cerebral disturbances, epigastric pain and/or lab abnormalities.CONCLUSION: Our findings did not demonstrate increased proteinuria in obese gravidas thus noting inconsistency with literature on non-pregnant populations. Study limitations include retrospective design with evaluation late in pregnancy. Further investigation is warranted prospectively in early pregnancy.
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