Here we report a general C(sp3)–H/C(sp3)–H dehydrogenative coupling
strategy for the preparation
of various natural or unnatural amino acids from readily available
glycine derivatives and hydrocarbons through a combination of SET
and HAT process.
We report a visible-light induced
redox-neutral decarboxylative
cross coupling reaction of indole-3-acetic acid NHPI esters with indoles
using a Ru photosensitizer to deliver a wide range of symmetrical
and unsymmetrical 3,3′-bisindolylmethane derivatives. Furthermore,
the reaction is readily adapted to the preparation of a wide variety
of diarylmethane derivatives.
A facile and efficient aerobic oxidative (4 + 2)-cyclization/aromatization/lactonization
tandem reaction of N-aryl glycine esters with propargyl
alcohols to access quinoline-fused lactones is reported. The reaction
can be extended to homopropargylic alcohols too. The transformation
is straightforward to perform under mild conditions and scalable,
and both reaction components are readily available.
We for the first time report a catalytic oxidative C-H cyanation of glycine derivatives using a simple copper (I) catalyst with NFSI as an oxidant via a radical process to...
Hydrofunctionalization of alkenes represents a fundamental strategy in synthetic organic chemistry. Herein, we describe a visible-light-promoted approach for the anti-Markovnikov hydrooxygenation of unactivated alkenes. Our protocol features the utilization of a cost-effective, bench-stable, and easyto-handle oxime ester as the reagent, enabled by energy-transfer catalysis. This methodology exhibits excellent functional group tolerance and mild reaction conditions, rendering it suitable for the hydroesterification of pharmaceutically relevant molecule-derived alkenes.
We describe a protocol to access quinoline-oxadiazole heterobiaryls. The oxidative (4 + 2)-cyclization/aromatization tandem reaction of N-aryl heteroaryl methanamines with alkenes or alkynes was realized by copper catalysis under aerobic condition.
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