A straightforward protocol for the visible‐light‐promoted decarboxylative 1,6‐conjugate addition of N‐aryl glycines to para‐quinone methides under transition‐metal‐free conditions is disclosed. This method provides scalable and efficient access to 2,2‐diarylanilines with biological and pharmacologic potential in good to excellent yields (39 examples, up to 97% yield). The synthetic utility of this work has been illustrated in the efficient synthesis of 3‐substituted indoline.
A general visible-light-induced photocatalyst-/additive-free strategy was developed for the construction of various nitrogen-heterocycles (42 examples, up to 97% yield) such as γ-lactams, δ-lactams, pyrrolidines, indolones, quinolinones, and fused polycyclic structures at room temperature. The prominent features of this protocol are mild and environmentally friendly conditions, broad substrate scope, and good functional group tolerance. Importantly, the reaction can be performed under natural sunlight, the most sustainable energy source imaginable. Furthermore, this strategy provides straightforward access to a range of derivatives through subsequent elaboration of the xanthate group.
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