Multifunctional compounds that can modulate amyloid- (A) aggregation and interact with metal ions hold considerable promise as therapeutic agents for Alzheimer's disease (AD). Using the copper-catalyzed azide-alkyne cycloaddition reaction, a novel bifunctional chelator 2-(1-(4-(dimethylamino)benzyl)-1H-1,2,3-triazol-4-yl)phenol (L1) was synthesized. L1 contains a bidentate metal-binding unit and a pendant dimethylamino moiety. The product was characterized by 1 H NMR, 13 C NMR, and MS. The metal-binding properties of L1 were probed by UV-vis spectroscopy to determine Cu:L stoichiometry. L1 was determined to limit A aggregation at 48 h via a ThT assay. In addition, L1 complies with Lipinski's rules and calculated logBB values for potential drug likeness and BBB permeability. These results suggest that L1 is a suitable candidate for further study as a multifunctional compound to treat AD.Résumé : Les composés multifonctionnels ayant la capacité de moduler l'agrégation de la -amyloïde (A) et d'interagir avec les ions métalliques sont des agents thérapeutiques fort prometteurs comme contre la maladie d'Alzheimer. Nous avons synthétisé, par réaction de cycloaddition catalysée par le cuivre entre un azoture et un alcyne, un nouveau chélateur bifonctionnel, le 2-(1-(4-(diméthylamino)benzyl)-1H-1,2,3-triazol-4-yl)phénol (L1). Le composé L1 comporte une unité bidentate se liant à l'atome métallique et un appendice portant un groupe diméthylamino. Nous avons caractérisé le produit par RMN 1 H, RMN 13 C et spectroscopie de masse (MS). Nous avons aussi étudié les propriétés de liaison à l'atome métallique du composé L1 par spectroscopie UV-vis afin de déterminer le rapport stoechiométrique Cu:L. À l'aide d'un essai à la thioflavine T (ThT), nous avons déterminé que le composé L1 limitait l'agrégation de l'Ab après 48 h. Par ailleurs, le composé L1 répond aux règles de Lipinski en ce qui concerne la pharmacopotentialité, et les valeurs calculées de son logBB sont compatibles avec la pénétration de la barrière hématoencéphalique. Ces résultats permettent de croire que le composé L1 vaut la peine d'être étudié davantage comme composé multif onctionnel dans le traitement de la maladie d'Alzheimer. [Traduit par la Rédaction] Mots-clés : -amyloïde, maladie d'Alzheimer, chimie clic, ions de cuivre.
It is known that polyamide 11 (PA11) is widely used in aviation, automobile, oil pipeline, gas engineering and other fields because of its excellent performance. However, pure PA11 as a carrier material of gas or liquid, its mechanical properties and barrier performance can not fully meet the application requirements in some circumstances, such as in narrow confined space or transporting flammable liquids. In this work, ternary blends were prepared by twin-screw extruder with PA11, ethylene-vinyl alcohol (EVOH) and modifier montmorillonite (MMT). The mechanical property, barrier functions, flame retardant performance and rheology of composites were studied. In comparison with those of the pure PA11, the impact properties, barrier properties and combustion intensity of ternary composites were significantly improved. Among them, the impact strength of the ternary composites (PA11/EVOH/ MMT = 67.5/22.5/10 wt%) was increased by 58% and the oil absorption value and peak heat release rate (PHRR) at this ratio were 0.190 and 164.124 w•g −1 , which were 23% and 43% of pure PA11, respectively. The addition of MMT had no obvious effect on ignition performance. All ternary composites were pseudo-plastic fluids and exhibited shear-thinning. SEM observation confirmed that composite materials changed from exfoliated composites to intercalated composites with an increase of the MMT content. The work offered the possibility of exploiting a high barrier performance low-cost polymer.
To mitigate the environmental hazards of boron mud waste accumulation, we prepared environmental-friendly SiO2 aerogels by extracting them through alkaline leaching treatment and optimized the experimental conditions. The optimum process parameters for alkaline leaching solution NaOH concentration, leaching temperature, solid-to-liquid ratio, and leaching time were 2 mol/L, 95 °C, 1:4, and 3 h, respectively. In this work, cheap and non-toxic hydroxy silicone oil (PDMS–OH) and hydrogen-containing silicone oil (PMHS) were used as surface modifiers instead of toxic and expensive trimethylchlorosilane (TMCS) in the SiO2 aerogel modification process. The best performance under the optimum conditions was achieved with 60% PDMS–OH-modified SiO2 aerogel. Organic liquid spills, represented by toluene, pose a great danger to the environment and water bodies. We treated free toluene on the water surface with the aerogel mentioned above and its adsorption capacity was up to 2,655 mg/g. After the adsorption of toluene, the aerogels coalesced into agglomerates for subsequent collection and handling. Furthermore, after five repeated applications, the adsorption capacity remained at 91.43% of the initial application. Overall, this research provided an inexpensive and simple solution for the treatment of organic liquids in wastewater.
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