A reaction of [Cp*RuCl]4 (Cp* = η5-C5(CH3)5) with K[HB(aza)3] (aza = 7-azaindolyl) afforded the first organometallic HB(aza)3− complex [Cp*Ru{HB(aza)3-κ3H,N,N′}], which lost one of the aza-units coordination upon treatment with carbon monoxide to give the mono(carbonyl) complex [Cp*Ru{HB(aza)3-κ2H,N}(CO)]. The crystal structures of these complexes have been determined by X-ray crystallography.
Polylactide (PLA)-grafted dextran (Dex-graft-PLA) of various contents of sugar units was synthesized by anionic polymerization of L-lactide (L-LA) using the alkoxide of partially trimethylsilylated dextran (TMSDex) and subsequently removing the trimethylsilyl (TMS) groups. The copolymer showed different solubility from L-LA homopolymer with increasing the content of sugar units. We prepared bovine serum albumin (BSA)-loaded microspheres (MS)s according to a water-in-oil-in-water emulsion-solvent evaporation/extraction method using methylene chloride/DMSO as an organic cosolvent. MSs prepared from Dex-graft-PLA [MS(Dex-graft-PLA)s] exhibited higher loading efficiency of BSA than MSs prepared from PLLA [MS(PLLA)s]. The in vitro release rate of BSA from MS(Dex-graft-PLA) was faster than that from MS(PLLA). BSA released from MS(Dex-graft-PLA) maintained the secondary structure of native BSA to a great extent, compared with BSA released from MS(PLLA).
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