This'll fix it: efficient fixation of atmospheric CO(2) has been achieved by the reaction of propargylic amines with a silver/DBU dual-catalyst system. Various oxazolidinones were synthesized in moderate to good yields by using substituted propargylic amines.
The first asymmetric total synthesis of (-)-HM-3 and (-)-HM-4, aromatic sesquiterpenes isolated from the phytopathogenic fungus Helicobasidium mompa, has been achieved. Highlight of the synthesis is an enantiospecific construction of the quaternary carbon stereocenter utilizing a palladium-catalyzed addition of arylboronic acid to the allenic alcohol followed by EschenmoserClaisen rearrangement.
A novel strategy for the one-pot synthesis of substituted pyridines from N-arylmethyl 3-aziridinylpropiolate esters is described. The method employs a three-step procedure including the formation of allenyl imines, phosphine-catalyzed cyclization, and subsequent oxidation of the dihydropyridines. Depending on the reaction conditions of the final oxidation step, tri- and tetrasubstituted pyridines can be selectively produced.
Total Synthesis of (-)-HM-3 (Ia) and (-)-HM-4 (Ib) Utilizing a Palladium--Catalyzed Addition of an Arylboronic Acid to an Allenic Alcohol Followed by Eschenmoser-ClaisenRearrangement. -(YOSHIDA*, M.; KASAI, T.; MIZUGUCHI, T.; NAMBA, K.; Synlett 25 (2014) 8, 1160-1162, http://dx.doi.org/10.1055/s-0033-1341059 ; Grad. Sch. Pharm. Sci., Univ. Tokushima, Sho, Tokushima 770, Japan; Eng.) -M. Tismer 44-207
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