Primary hepatic mucosa-associated lymphoid tissue (MALT) lymphoma is an extremely rare disease. A 65-year-old female patient with chronic hepatitis B presented with multiple solid masses in segment (S) 4, S5, and S6 of the liver. The nodule in S5 was diagnosed preoperatively as hepatocellular carcinoma by computed tomography, magnetic resonance imaging, and angiography. The nodule in S4 was initially interpreted as lymphoid follicles by needle biopsy. Segmentectomy of S5 and partial resection of S6 were performed. Microscopic examination of the S5 nodule revealed moderately differentiated hepatocellular carcinoma. The nodule from S6 showed nodular proliferation of atypical intermediate to medium-sized lymphoid cells in the portal area and lymph epithelial lesions of bile ducts. The atypical lymphoid cells were positive for LCA, L-26 and bcl-2 and negative for UCHL-1. These features were consistent with the diagnosis of MALT lymphoma. This is the first case report of synchronous hepatic MALT lymphoma and hepatocellular carcinoma associated with chronic hepatitis B.
A 71-year-old man visited our hosptial with the chief complaint of a mass in the left epigastric region. MDL revealed a compresed area ranging from the fundus ventriculi to the corpus ventriculi, and CT revealed a giant mass with an uneven interior. Angiography revealed dilatation of the celiac, splenic and hepatic arteries and indicated that the tumor mass was nourished mainly by the splenic artery. Because gastric sarcoma was suspected, surgery was performed on the patient. The mass, which was found to have developed extramurally, was connected with the diaphragm and the left lobe of liver. The left lobe and part of the diaphragm were resected, together with total gastrectomy. Histopathologicaly examination revealed that the tumor originating from the left lobe of the liver had developed extensively and extended extrahepatically. It was evaluated as Ed-grade II to III hepatocellular carcinoma with infiltration into the anterior wall of the stomach. Three months after surgery the patient was discharged from the hospital, but the metastatic lesions to the liver gradually enlarged. In spite of the injection of mitomycin C or lipiodol into the hepatic artery, the patient died of liver failure seven months after surgery.The present case of liver cancer with extrahepatic development, a relatively rare condition, is discussed with a review of 62 cases reported in the Japanese literature and with reference to other literature.
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