Three types of cDNA clone of the protein kinase C family termed 6, Eand < were newly identified by molecular cloning and sequence analysis. These members have a common structure that is closely related to, but clearly different from the other four known members of the family which have LX-, PI-, PII-and y-sequences, although the I-cDNA available at present does not contain a complete reading frame for a protein kinase C molecule. The diverse heterogeneity of the enzyme seems to be an important factor in determining the mode of response of many tissues and cell types to a variety of external stimuli.Protein kinase C; cDNA; (Rat brain)
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