The copper-catalyzed regioselective intermolecular hydroamination of the aryl and trifluoromethyl group or electron-withdrawing group substituted internal alkynes with amines has been accomplished. The reaction was effectively catalyzed by the ligand-free Cu(OTf)2 and afforded the intended amine derivatives in good yields after treatment of NaBH3CN.
Iron-catalyzed [2 + 2 + 2] intermolecular cycloaddition of trifluoromethyl group substituted unsymmetrical internal alkynes afforded the corresponding trifluoromethyl group substituted benzene derivatives in high yield with excellent selectivity.
We demonstrated the intermolecular [2+2+2] cycloaddition of aryl-and trifluoromethyl-substituted internal alkyne and ethyl cyanoformate, and succeeded in constructing the pyridine derivatives using the CoI 2 /dcype/Zn catalyst system. The reaction proceeded with a high regioselectivity, and two trifluoromethyl-substituted ethyl picolinate derivatives were obtained as a single regioisomer.
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