Introduction: Oxidative stress plays a central role in the development and progression of vascular complications in patients with type 2 diabetes mellitus (T2DM). We have previously shown that markers of glucose variability evaluated by continuous glucose monitoring (CGM) are positively associated with oxidative stress in patients with T2DM. However, the evaluation of the glycemic variability by CGM remains a time-and money-consuming procedure. Therefore, this study investigated the independent correlates of oxidative stress among various other clinical markers routinely measured in primary care. Methods: This was a retrospective cross-sectional study with 234 T2DM patients to examine which clinical variables, including 1,5anhydro-D-glucitol (1,5-AG) and glycated albumin (GA), were independently associated with oxidative stress. Oxidative stress was measured using the diacron-reactive oxygen metabolites (d-ROMs) test. The relationships between d-ROMs and clinical factors, such as blood glucose, glycated hemoglobin (HbA1c), 1,5-AG, GA, lipid parameters, and blood pressure, were examined. Results: Multiple stepwise regression analysis revealed that 1,5-AG (inversely), GA, triglycerides, use of metformin and being female were independently associated with d-ROMs. When patients with T2DM were stratified into two groups with HbA1c \ 8.0% and HbA1c C 8.0%, 1,5-AG (inversely), HbA1c, use of metformin and being female were independently associated with d-ROMs in diabetes patients with HbA1c \ 8.0%, whereas GA, fasting plasma Enhanced Digital Features To view enhanced digital features for this article go to https://doi.org/10.6084/ m9.figshare.11605017.

Our GWAS identified 22 independent loci showing suggestive association signals with degenerative bony changes of the TMJ. These loci provide good candidates for future follow-up studies.

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Contact state of upper and lower teeth is very important for diagnostic treatment of occlusal disorders. This paper discusses a 3-D motion display system with a patient-specific hybrid model to analyze detailed contact state of upper and lower teeth. The hybrid model consists of maxillary and mandibular bone data with cone beam X-ray CT and precise teeth shape data with industrial X-ray CT. In terms of 3-D motion measurement, appropriate camera angles and frame rates are also discussed to improve the accuracy of the display system. With these improvements, this study achieves 0.1 mm accuracy which enables to evaluate the contact state of teeth. Several masticatory movements are analyzed with the new system and the analytical results provide detailed information of contact state during mastication of foods.