It is suggested that plasmin, but not histamine, is involved in extravasation by OA. Inhibition of plasmin can be an effective strategy for treatment of this kind of lung injury.
Additional evidence supporting a hypothesis previously presented by the authors' that a piperidino group strengthens and increases antitussive activity is presented. The role of pyrrolidino groups in antitussive activity has also been studied.In a study of structure-activity relationship in anti-
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