To examine the possibility of diagnosing Alzheimer-type dementia, we studied this condition using the run length matrix, on head MR images of 29 Alzheimer-type dementia patients (8 men, 21 women, 78.7 +/- 6.7 years) and healthy elderly controls (10 men, 19 women, 72.3 +/- 8.7 years) . The results showed that differences in GLN (gray level nonuniformity) and RLN (run length nonuniformity) were statistically significant. Furthermore, discriminant analysis based on GLN and RLN showed a rate of sensitivity of 69.0%, specificity 86.2%, and correct classification 77.6%. Although this rate of correct classification is inferior to the planimetric and volumetric methods, run length matrix is only one method of texture analysis. The results of this study indicate the possibility of MR imaging-based diagnosis of Alzheimer-type dementia with texture analysis including a run length matrix.
In order to develop the effective evaluation system for the fatigue of operator's visual system in long term operation, the experiments were carried out utilizing perceptual time duration of motion aftereffect (MAE), critical flicker frequency (CFF) and the near point (NP) measurement. The MAE was measured using rotated spiral figure displayed on a CRT screen. To generate visual fatigue, a signal detection task in randomly displayed alphabets was used. After the task, MAE duration, CFF and NP were increased. It is supposed that the visual fatigue generated by the experimental task affects motion processing system of visual cortex. Results suggest that the MAE can be an effective tool for visual fatigue evaluation.
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