Metastasis to lymph nodes from oral squamous cell carcinoma (OSCC) without neck dissection classification (lingual lymph nodes (LLN) and lateral retropharyngeal lymph nodes (LRPN) ) is rare and difficult to deal with. The aim of the present study was to assess the treatment modality and prognosis of LLN and LRPN in patients diagnosed with OSCC. This retrospective study involved a chart review of the clinical records of OSCC patients diagnosed with LLN or LRPN metastasis between June 2008 and March 2021. Data were collected and treatment outcomes were analyzed. Two OSCC patients with primary LRPN metastasis underwent LRPN dissection or superselective intra-arterial chemoradiotherapy. One patient with recurrent lateral LLN underwent surgery. Seven patients with recurrent LRPN and 7 patients with recurrent para-hypoid lymph nodes underwent chemoradiotherapy, bioradiotherapy, immune checkpoint inhibitors (ICIs) or best supportive care. The cumulative 1-year overall survival rate was 25.8% on LLN (especially para-hyoid lymph node) , and 33.3% on LRPN. Cetuximab or ICIs are important to determine an effective treatment strategy for LLN or LRPN metastasis in the future.
A retrospective review was performed in 66 patients and 75 tumors with KCOT who underwent surgery and were followed up for at least 6 months at Nagasaki University Hospital from 1992 to 2014.KCOT occurred more frequently in men (57.6%) than in women (42.4%) , and occurred most commonly in the second decade (24.2%) , followed by the first decade (19.7%) ; the mean age of patients was 36 years old. The most frequent clinical complaint at first admission was asymptomatic, followed by painless swelling and painful swelling. The mandibular molar and ramus were the most common sites of involvement. Surgical procedures included enucleation (84.0%) and marsupialization before enucleation (16.0%) . The patients were followed for 6 to 252 months. Recurrences were found in 15 out of 75 tumors (20.0%) . Univariate and multivariate analysis showed that treatment of the tooth root in contact with the primary lesion is a significant independent factor for recurrence (P < 0.05) .It is suggested that the tooth root in contact with the primary lesion should be extracted to reduce the incidence of recurrence. The period between primary operation and recurrence ranged from 10 to 137 months. For these reasons, careful long-term follow-up is required. :keratocystic odontogenic tumor(角化囊胞性歯原性腫瘍) ,recurrence(再発) ,clinical study(臨床的検討)
A Case of Glandular Odontogenic Cyst in the Mandibular Region KOHEI FURUKAWA, TOMOFUMI NARUSE, KOHEI OKUYAMA, SOUICHI YANAMOTO, NAOKI KATASE * AND MASAHIRO UMEDA :Glandular odontogenic cyst (GOC) is a rare odontogenic cyst derived from odontogenic epithelium; GOC shows aggressive behavior, unpredictable recurrence and rarely, malignant transformation. We describe our experience with a case
Most patients experience postoperative complications caused by the extraction of impacted mandibular horizontal third molars. The aim of the present study was to compare the effects of two flap designs as a refinement on the reduction of postoperative complications. One hundred eighty-eight patients with impacted mandibular horizontal third molars were included in this single-blind, multicenter, randomized control trial. The allocation was determined using a modified envelope flap (mEF) and triangular flap (TF) at 1:1 by the data manager. Postoperative complications (pain, hemorrhage, nerve paralysis, dry socket, and infection) and operation time were assessed 7 ± 1 days after surgery. In all cases, postoperative pain was significantly lower in the mEF group (P<0.05). In the subgroup analysis, postoperative pain was significantly lower in patients with low difficulty (IA, IIA, IIA, IB), which were classified by G.B. Winter classification (P<0.05). Other factors were not significantly associated with the flap design. Our study suggests that mEF resulted in less postoperative pain with a low difficulty of impacted mandibular horizontal third molars. However, the evidence at present is not sufficient to suggest the use of either flap design.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.