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Our results suggest that asthma-predicting Rint and, to a lesser extent, asthma-predicting FeNO, defined in the present study, could serve as a reliable tool to exclude asthma in schoolchildren. However, our results also indicate a clinically important fact that all lung function parameters or FeNO should be interpreted in the context of age, gender, allergy profile, and the presence of co-morbidities in schoolchildren. Pediatr Pulmonol. 2014; 49:632-640. © 2013 Wiley Periodicals, Inc.

Introduction The changing outcomes for young cystic fibrosis (CF) patients means that reproductive health issues have become an integral part of CF management. Aim The aim of this study was to investigate the knowledge and experiences of reproductive and sexual health issues in women with CF and to investigate the knowledge and reproductive health attitudes of their parents. Main Outcome Measures Assessment of reproductive and sexual health knowledge in female CF patients and their parents. Methods A questionnaire study directed to 120 Polish women with CF aged 16 years and older and their parents. Results Sixty-four patients and their parents responded to the questionnaire. Sixty-eight percent of the patients started sexual intercourse at a mean age of 19.2 years. Eighty-four percent of all sexually active women reported that they did not use any form of contraception. Only 32.8% of women understood the problems connected with their own and male fertility in CF. Popular scientific publications and other CF patients were identified as the most important source of information. Only 23% of parents understood the problems connected with female fertility in CF; 44% of parents thought that man with CF had normal fertility. Seventy-five percent of the women and 40% of the parents felt that sexual health discussions should begin between age 12 and 14 years with a CF doctor and the mother. Conclusions Our study showed that significant knowledge gaps exist regarding fertility issues in both CF patients and CF parents. Women with CF have some general knowledge about sexual issues but insufficient knowledge to have a safe sexual life. The results helped us to develop the educational program for CF patients.

randomized, double-blind trial of the effect of anti-asthma treatment on lung function in children with asthma. Pulmonary Pharmacology Therapeutics, 2007, 20 (6) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. showed significantly greater effects on Rint than monotherapy: BM group compared to B group (P =0.01) and M group (P =0.03) and BF group compared to B group (P =0.01) and M group (P =0.04). Conclusion:This study shows that using single parameter for monitoring asthma can be misleading. Using combination of lung function techniques provides better assessment of treatment. Results of our study confirm this hypothesis. The best effect on large and small airways was achieved with combined anti-inflammatory therapy. 2A c c e p t e d m a n u s c r i p t A c c e p t e d m a n u s c r i p t

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BACKGROUND:The clinical implications of fractional exhaled nitric oxide (F ENO ) measurements in childhood asthma are unclear. We aimed to evaluate the relationship between the level of exhaled nitric oxide and pre-bronchodilator FEV 1 and the change in FEV 1 after bronchodilator in children with asthma. METHODS: This was a retrospective, cross-sectional study. We evaluated data from medical documentation of children with asthma with special attention to F ENO results, asthma severity, FEV 1 (% predicted), and bronchial reversibility test. RESULTS: Four hundred and five subjects (age 6 -18 y) completed the study. Median levels of F ENO increased linearly with subjects' age (P ‫؍‬ .03). We found a nonlinear trend of pre-bronchodilator FEV 1 across 4 quartiles of F ENO in episodic and mild asthma; we observed lower pre-bronchodilator FEV 1 in children with higher F ENO , but only up to the F ENO value of 35.4 ppb; in children with F ENO value > 35.4 ppb, prebronchodilator FEV 1 was increased. We found a linear increasing trend of change from baseline (after 400 g of salbutamol) in FEV 1 across F ENO categories in children with moderate asthma. CONCLUSIONS: Our results suggest a need to measure F ENO before as well as after spirometry. Consequently, in children with asthma with bronchial obstruction, we suggest assessing F ENO after short-acting ␤ 2 agonists as well. (ClinicalTrials.gov registration NCT00815984.)

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