Aim: Metabolic syndrome (MeS) refers to metabolic risk factors with different phenotype combinations. The study aim was to determine the clusters of MeS components by age and gender as predictors for the presence of fatty liver (FL). Materials and Methods: The cohort consisted of 990 subjects, undergoing executive health check between January 2019 and February 2020. Baseline data, anthropometric parameters, and ultrasound findings were noted. Patients with normal ultrasound were categorized as group 1 and those with FL as group 2. MeS is defined and clustered and risk of predicting FL was analyzed in age and gender. Results: Of the 990 subjects, 689 (69.6%) had FL (group 2); 554 patients (56%) were >45 years. Females had significant grade 1 (P < 0.05) and grade 2 (P < 0.01) FL, ≥45 years, and MeS of three or more components in FL, both above (P < 0.01) and below (P < 0.03) 45 years of age. Waist circumference (WC), diabetes mellitus (DM) with hypertension, triglyceride, and high-density lipoprotein (cluster 3) were statistically significant in males, both <45 and >45 years of age (P < 0.001); in females, the same cluster was statistically significant only for >45 years (P <0.001). Conclusion: Females ≥45 years had significant FL. MeS of three or more components was seen in both above and below 45 years in females with FL when compared with males. The highest risk clusters were the ones that included WC and WC + DM, indicating that the clusters associated with WC alone or in combination with DM had the highest risk for FL when compared with the other MeS combinations.
Background: FIB 4 score is known to have a significant negative and positive predictive value in predicting lower and higher grades of liver fibrosis. Aim: To determine the cut off of FIB-4 in patients with a normal ultrasound and in those with Fatty Liver (all grades) as a predictor of fibrosis. Methods: Prospective data on hemogram, liver biochemistry and ultrasound (USG) were collected in Master Health Check (MHC). USG findings were classified as normal Grade 1, 2 and 3 FL.FIB-4 were calculated. Patients with known liver disease were excluded. Statistical Analysis: Appropriate non parametric tests were used. AUROC was obtained for FIB-4 cut off. SPSS version 23v was used. Results: There were 741 subjects (274 men; 64%). 418 (56.4%) were > 45 years. Liver was normal in 297 (40.1%); grade 1, 2 and 3 FL in 293 (39.5%), 114 (15.4%) and 37 (5%) subjects respectively. The overall mean FIB-4 score was high in males (1.37 ± 1.06 vs 1.15±0.83, p value 0.009) and remained so for age > 45 years (1.69+ 1.09 versus 1.33+ 0.88, p value 0.000). Mean FIB-4 scores increased with grades of FL (p 0.126). AUROC was 0.538, 0.516 and 0.602 respectively for Gr 1, 2 and 3 respectively. Conclusion: FIB-4 score in our study is lower than that reported in the west with poor prediction for any grade of FL.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.