Abstract-Mobile users of future ubiquitous environments require novel means for locating relevant services available in their daily surroundings, where relevance has a user-specific definition. In this paper, we propose the hybrid service provisioning model which complements the traditional model of interaction service provider to consumer with peer-to-peer functionalities. In addition to being notified proactively and in a context-aware manner about services available in the surroundings, users can generate several types of contextual messages, attach them to services or to the environment, and share them with other peers. We have designed and implemented a platform that supports this hybrid service provisioning model. The current application prototype runs on commercial smart phones. To demonstrate the feasibility and technical deployability of our approach, we conducted field trials in which the research subject was a community of recreational boaters.

Toll-like receptor 5 ligand, flagellin, and Vascular Adhesion Protein-1 (VAP-1) are involved in non-alcoholic fatty liver disease (NAFLD). This study aimed to determine whether VAP-1 mediates flagellin-induced hepatic fat accumulation. The effects of flagellin on adipocyte VAP-1 expression were first studied in vitro. Then, flagellin (100 ng/mouse) or saline was intraperitoneally injected to C57BL/6J WT and C57BL/6-Aoc3-/- (VAP-1 KO) mice on high-fat diet twice a week every two weeks for 10-weeks. After that, the effects on inflammation, insulin signaling, and metabolism were studied in liver and adipose tissues. Hepatic fat was quantified histologically and biochemically. Because flagellin challenge increased VAP-1 expression in human adipocytes, we used VAP-1 KO mice to determine whether VAP-1 regulates the inflammatory and metabolic effects of flagellin in vivo. In mice, VAP-1 mediated flagellin-induced inflammation, leukocyte infiltration and lipolysis in visceral adipose tissue. Consequently, increased release of glycerol led to hepatic steatosis in WT but not KO mice. Flagellin-induced hepatic fibrosis was not mediated by VAP-1. VAP-1 KO mice harbored more inflammation-related microbes than WT, while flagellin did not affect the gut microbiota. Our results suggest that by acting on visceral adipose tissue, flagellin increased leukocyte infiltration that induced lipolysis. Further, the released glycerol participated in hepatic fat accumulation. In conclusion, the results describe that gut microbial flagellin through VAP-1 induced hepatic steatosis.

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Dosimetry of neutron beams for BNCT involves characterization of the neutron¯ux in the free ®eld as well as characterization of¯ux, KERMA, and dose distributions in realistic phantoms and in vivo. Activation dosimeters and paired ion chambers are commonly used for this application and advanced techniques, especially for in vivo applications (e.g. scintillating glass ®bres) are under investigation.Computational dosimetry and treatment planning techniques for BNCT have evolved along two lines in the US. Both approaches are based on direct construction of patient geometry from medical images, followed by explicit multidimensional Monte Carlo calculations of the expected radiation dose distribution, given a description of the incident neutron source. The two approaches differ, however, in the speci®c methods used for the reconstruction and¯ux calculation. In this respect, one approach is based on use of standard general-purpose Monte Carlo software, while the other employs special-purpose radiation transport software that has been optimized for medical applications involving neutron transport.

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