The syntheses of the potential heterocyclic amine food mutagens, 3,5,7‐trimethyl‐2‐aminoimidazo‐[4,5‐b]pyridine, 1,4,7‐trimethyl‐2‐aminoimidazo[4,5‐c]pyridine, 1,6,7‐trimethyl‐2‐aminoimidazo[4,5‐c]‐pyridine, 3,4,6‐trimethyl‐2‐aminoimidazo[4,5‐c]pyridine, and 1,4,6‐trimethyl‐7‐aminoimidazo[4,5‐c]‐pyridine are described.
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Syntheses of 1,5,6-Trimethyl-2-aminoimidazo(4,5-b)pyridine and 3,5,6-Trimethyl-2-aminoimidazo(4,5-b)pyridine.-The title compounds (VII) and (XV) are mutagens which cause cancer. They are formed during the heating of protein-containing foods. -(TANGA, M. J.; BUPP, J. E.; TOCHIMOTO, T. K.; J. Heterocycl. Chem. 31 (1994) 6, 1641-1645; SRI Int.,
Syntheses of Five Potential Heterocyclic Amine Food Mutagens. -Isomers of trimethyl-aminoimidazopyridine are among those heterocyclic amines which are present in the human dietary intake. To investigate the biological risk associated with the single isomers, syntheses of compounds (I)-(V), not previously reported in the literature, are performed. -(TANGA, M. J.; BUPP, J. E.; TOCHIMOTO, T. K.; J. Heterocycl. Chem. 34 (1997) 3, 717-727; SRI Int.,
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