Highlights d SCA7 mice display increased histone H3 promoter Ac in DNA repair genes in cerebellum d DNA damage is elevated in SCA7 cells, primary neurons, and patient stem cell neurons d DNA repair assays in cells expressing polyQ-ataxin-7 show deficits in specific pathways d LAM-HTGTS identifies altered repair processes on endogenous DNA in SCA7 cell models
Gambling disorder (GD) is associated with a higher prevalence of adverse childhood experiences (ACEs). Whether this applies to groups such as U.S. veterans, who already have elevated ACEs, is not known. In this pilot study, we extracted ACEs from the charts of a random sample (n = 19) male veterans in residential GD treatment and compared them to those from a general veteran sample (n =154, 30 females, 124 males). The GD group had an elevated prevalence (79% vs. 37%) of three or more ACEs and a lower prevalence (5% vs. 49%) of one or fewer ACEs. Within groups with elevated ACEs, higher ACE load may still confer a higher risk of adult GD.
This paper investigates COVID-19 exported cases by country and the time it takes between entry until case confirmation for the exported cases using publicly available data. We report that the average days from entry to confirmation is 7.7, 5.0 and 4.7 days for travelers from China, Italy, and Iran respectively. Approximately, one-third of all exported cases were confirmed within 3 days of entry suggesting these travelers were mildly symptomatic or symptomatic in arrival. We also found that earlier exported cases from each country had a longer time between entry to confirmation by an average of 3 days compared to later exports. Based upon our data, reported exported cases from South Korea were far fewer in comparison to those from China, Italy and Iran. Therefore, we suggest that careful monitoring of likely symptomatic travelers and better public awareness may lead to faster confirmation as well as reduced transmission of COVID-19 pandemic.
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