Ninety-three thromboembolic occlusions of peripheral arteries or grafts in 85 patients John R. Fischer1were treated with high-dose urokinase by direct intraarterial infusion. Urokinase was infused at 4000 lU/mm until antegrade blood flow was reestablished and then at 1000 or 2000 lU/mm until clot lysis was completed. Of the 93 infusions, 75 (81%) resulted in clinical improvement. The infusion therapy was incomplete in nine patients. The mean duration of the 84 completed infusions was 18 ± 20 hr, the incidence of complete clot lysis was 83%, and the incidence of clinical improvement was 89%. Significant bleeding, requiring transfusion, occurred during or after four of the urokinase infusions (4%).
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