Introduction and Materials and Methods:In the clinic of orthopedics and trauma North-western State Medical University named after I.I. Mechnikov from 01.01.2022 to 15.12.2022, a total of 187 total knee replacement (TKR) were done in patients with osteoarthritis. A random sample taken for histological studies from 30 patients aged 40 to 76 years (19 F, 11 M). Samples were prepared according to the standard protocol for bone tissue, the bone fragments tested were decalcified in electrolyte decalcification solution (Biovitrum, Russia). Histological processing, pouring, and microtomy with a section thickness of 5 μm were performed as per standard protocol. The preparations were stained with dyes (hematoxylin and eosin) and safranin O.Results: Only 48 (25.7%) patients before TKR were at least once had inpatient conservative or minimally invasive surgical treatment for osteoarthritis of the knee joint. 18 (9.6%) patients had intraoperative and postoperative complications. Among the 30 morphological studies performed, 3 (10%) patients grade I, 8 (26.7%) subjects grade II, and in 19 (63.3%) -grade III osteoarthritis of the knee joint was diagnosed.Conclusions: Among patients who underwent TKR, only one in four (48 people -25.7%) was at least once had inpatient conservative or minimally invasive surgical treatment for OA. According to the morphological study, 11 (36.7%) clinical observations undergoing arthroplasty were verified as grade I-II OA. To form a strategy for the treatment of patients with osteoarthritis of knee joint, it is vital to develop an algorithm for teamwork between therapist, orthopedic surgeon, rheumatologist, rehabilitation medicine specialist, specialists in restorative medicine and healthcare organizers in the process.Such results are given by russian scientists. In 2019, A.V. Lychagin., et al. studied the validity of TKR in elderly patients. The
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