Delivery of ASOs targeting mRNAs encoding each of the three ENaC subunits directly into the lung improved disease phenotypes in a mouse model of CF-like lung disease. These findings suggest that targeting ENaC subunits could be an effective approach for the treatment of CF.
A total of 64 patients with β-lactam allergy and 30 control subjects were enrolled in a case-control study.This study is aimed to analyze the relationship between β-lactam allergy and 10 single nucleotide polymorphisms (SNPs) in interleukin-10 (IL-10), IL-13, IL-4Rα, high-affinity immunoglobulin E-receptor β chain (FcεRIβ), interferon γ receptor 2 (IFNGR2), and CYP3A4, and within the Han Chinese population of Northwest China. Genotyping for the SNPs was conducted using the Sequenom MassARRAY ® platform. SPSS 17.0 was employed to analyze the statistical data and SHEsis was used to perform the haplotype reconstruction and analyze linkage disequilibrium of SNPs of IL-10 and IL-13. The results showed that the genotype distribution of CYP3A4 rs2242480/CT differed significantly between case and control groups of males (P=0.022; odds ratio (OR)=0.167, 95% confidence interval (CI): 0.032-0.867). Further analysis showed that CCA, CCG, and TAA haplotypes of IL-10 had no significant correlation in patients with β-lactam allergy. The correlation between CCT and CAC haplotypes of IL-13 and β-lactam allergy needs to be further studied. The analysis did not reveal any differences in the distribution of others gene polymorphisms between cases and controls.
The ezomycins make up a class of
complex nucleoside antibiotics
that share a common disaccharide core. Herein we present an efficient
synthesis of this core from diacetone-d-allose, using a ruthenium-catalyzed
asymmetric allylic etherification and a de novo carbohydrate
synthesis based on the diastereoselective Henry reaction. Our strategy
overcomes several challenges, such as introducing a dense array of
functional groups and creating consecutive stereocenters with high
selectivity. This approach enables the rapid preparation of disaccharides
and paves the way for the total synthesis of ezomycins.
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