3D medical image registration is of great clinical importance. However, supervised learning methods require a large amount of accurately annotated corresponding control points (or morphing), which are very difficult to obtain. Unsupervised learning methods ease the burden of manual annotation by exploiting unlabeled data without supervision. In this paper, we propose a new unsupervised learning method using convolutional neural networks under an end-to-end framework, Volume Tweening Network (VTN), for 3D medical image registration. We propose three innovative technical components: (1) An end-to-end cascading scheme that resolves large displacement;(2) An efficient integration of affine registration network; and (3) An additional invertibility loss that encourages backward consistency. Experiments demonstrate that our algorithm is 880x faster (or 3.3x faster without GPU acceleration) than traditional optimization-based methods and achieves state-of-theart performance in medical image registration.
Modern classification algorithms are susceptible to adversarial examplesperturbations to inputs that cause the algorithm to produce undesirable behavior. In this work, we seek to understand and extend adversarial examples across domains in which inputs are discrete, particularly across new domains, such as computational biology. As a step towards this goal, we formalize a notion of synonymous adversarial examples that applies in any discrete setting and describe a simple domain-agnostic algorithm to construct such examples. We apply this algorithm across multiple domains-including sentiment analysis and DNA sequence classificationand find that it consistently uncovers adversarial examples. We seek to understand their prevalence theoretically and we attribute their existence to spurious token correlations, a statistical phenomenon that is specific to discrete spaces. Our work is a step towards a domain-agnostic treatment of discrete adversarial examples analogous to that of continuous inputs.
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