Constructing the interconnected porous biomaterials scaffolds with osteogenesis and angiogenesis capacity is extremely important for efficient bone tissue engineering. Herein, we fabricated a bioactive micro-nano composite scaffolds with excellent
in vitro
osteogenesis and angiogenesis capacity, based on poly (lactic-co-glycolic acid) (PLGA) incorporated with micro-nano bioactive glass (MNBG). The results showed that the addition of MNBG enlarged the pore size, increased the compressive modulus (4 times improvement), enhanced the physiological stability and apatite-forming ability of porous PLGA scaffolds. The
in vitro
studies indicated that the PLGA-MNBG porous scaffold could enhance the mouse bone mesenchymal stem cells (mBMSCs) attachment, proliferation, and promote the expression of osteogenesis marker (ALP). Additionally, PLGA-MNBG could also support the attachment and proliferation of human umbilical vein endothelial cells (HUVECs), and significantly enhanced the expression of angiogenesis marker (CD31) of HUVECs. The as-prepared bioactive PLGA-MNBG nanocomposites scaffolds with good osteogenesis and angiogenesis probably have a promising application for bone tissue regeneration.
In situ printing gives insight into the evolution of morphology and optical
properties during slot-die coating of active layers for application
in organic solar cells and enables an upscaling and optimization of
the thin film deposition process and the photovoltaic performance.
Active layers based on the conjugated polymer donor with benzodithiophene
units PBDB-T-2Cl and the non-fullerene small-molecule acceptor IT-4F
are printed with a slot-die coating technique and probed in
situ with grazing incidence small-angle X-ray scattering,
grazing incidence wide-angle X-ray scattering, and ultraviolet/visible
light spectroscopy. The formation of the morphology is followed from
the liquid state to the final dry film for different printing conditions
(at 25 and 35 °C), and five regimes of film formation are determined.
The morphological changes are correlated to changing optical properties.
During the film formation, crystallization of the non-fullerene small-molecule
acceptor takes place and polymer domains with sizes of some tens of
nanometers emerge. A red shift of the optical band gap and a broadening
of the absorbance spectrum occurs, which allow for exploiting the
sun spectrum more efficiently and are expected to have a favorable
effect on the solar cell performance.
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