A simple, mild and efficient approach for the fluoroalkylation of alkenes and alkynes using 2-bromophenol as a catalyst is presented.

The first example of visible light promoted fluoroalkylation reactions initiated via noncovalent interactions between solvents and RFI is presented.

Atom transfer radical addition and Heck-type reaction between alkenes and ethyl iododifluoroacetate by using organophosphine compounds as catalysts have been developed. The reaction proceeds under mild reaction conditions with excellent functional group tolerance and high chemo-and regioselectivities. Mechanistic study indicates that the reaction might be initiated via noncovalent interactions between an organophosphine catalyst and a carbon−iodine bond.

Here, we describe a mild, catalyst-free and operationally-simple strategy for the direct fluoroalkylation of olefins driven by the photochemical activity of an electron donor−acceptor (EDA) complex between DMA and fluoroalkyl iodides. The significant advantages of this photochemical transformation are high efficiency, excellent functional group tolerance, and synthetic simplicity, thus providing a facile route for further application in pharmaceuticals and life sciences.Molecules 2020, 25, 508 2 of 8 mild, catalyst-free and operationally-simple strategy for the direct fluoroalkylation of olefins driven by the photochemical activity of electron donor−acceptor (EDA) complex between DMA and fluoroalkyl iodides. The significant advantages of this photochemical transformation are high efficiency, excellent functional group tolerance, and synthetic simplicity [52].

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We demonstrated a practical and general methodology for the synthesis of secondary trifluoromethyl boronic esters through visible light induced decarboxylative alkylation reaction. This reaction was driven by the photochemical activity of electron donor-acceptor (EDA) complex. Except for wide group tolerance, moderate to high yields and simple reaction conditions, the practicality of this protocol was further demonstrated by direct modification of bioactive molecules and further derivations.

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