Background Hypocalcemia is a common complication after total parathyroidectomy(t-ptx) in patients with secondary hyperparathyroidism(SHPT), which endangers the lives of patients, but the amount of intravenous calcium supplementation is very different in each patient.Therefore,We aimed to elop a predictive model of intravenous calcium supplementation needs in patients with SHPT after t-ptx.Methods Data for 550 SHPT patients treated in the Department of Hepatobiliary Surgery of the Northern Theater General Hospital were collected from January 2015 - December 2021, with patient biochemical indices being retrospectively evaluated.Results Sex (t=-1.988, p=0.049), serum ferriti (SF) (t=2.155, p=0.033), alkaline phosphatase (AKP) (t=4.501, p=0.000), free thyroxine (FT4) (t=-3.128, p=0.002) were identified as risk factors associated with the need for postoperative intravenous calcium supplementation. The developed predictve model (intravenous calcium supplementation =1235.561-158.547*gender + 0.141*SF + 0.442*AKP - 494.055*FT4; male: 0, female: 1) was effective and passed the F test (F = 22.034, P = 0.000).Conclusions The developed model can be used to reliably predict the amount of intravenous calcium supplementation required by SHPT patients following t-ptx, providing a clinical basis for an evidence-based calcium supplementation scheme.
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