Using a family of novel mononuclear and dinuclear palladium complexes of phanephos ligands, the simultaneous control of regioselectivity and enantioselectivity in the hydroxycarbonylation and alkoxycarbonylation of styrene derivatives has been realised for the first time.
MatPhos, a good mate for hard tasks: The asymmetric hydrogenation of 1-alkyl vinyl esters, thwarted so far by mediocre ee values and low activities, can now be achieved with MatPhos/Rh catalysts with ee values of 96-99% for a variety of substrates at low catalyst loadings (0.1-1 mol %) and under mild conditions (5-20 bar H2, room temperature). After hydrolysis, the corresponding chiral secondary alkyl alcohols can be obtained in high enantiopurities providing a general and practical route to this important product class.
Palladium hoch zwei: Neuartige dimere Palladiumkatalysatoren wie 1 mit einem planar‐chiralen Diphosphan als Brückenligand vermitteln die hoch enantioselektive Hydroxycarbonylierung von Alkenen – eine Reaktion, die sich bisher als problematisch erwiesen hatte. PTSA=para‐Toluolsulfonsäure.
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