Dantrolene represents yet another
interesting example of abundant
molecular crystal polymorphism existing in at least six different
neat polymorphs, three of which can be obtained via crystallization
(I–III) and an additional three (IV– VI) via solid-state
dehydration from three different monohydrates (MH-I–MH-III).
The reasons for polymorph formation were rationalized by analyzing
the crystal structures of the polymorphs and hydrates used in their
preparation. The thermodynamic relations among the polymorphs were
established from calorimetric data, solubility measurements, and lattice
energy calculations.
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