A survey was made of the work and hobbies of 658 patients with the carpal tunnel syndrome. Seventy-nine per cent of the patients were employed in work requiring light, highly repetitive movements of the wrists and fingers. Fifty-one per cent of the unemployed housewives knitted. It is suggested that this type of manual activity can be a causal factor in the development of the, so-called, 'spontaneous' carpal tunnel syndrome.

Many cases of ultrahyperferritinemia are caused by a combination of multiple distinct etiologies. Cases of ultrahyperferritinemia among patients with ESRD and myelodysplastic syndrome may be partially explained by their often concomitant chronic blood transfusions. Acute liver injury is by far the most common cause of ultrahyperferritinemia caused by a single etiology, even at the most astronomically elevated serum ferritin concentrations. Finally, patients with ultrahyperferritinemia caused by malignancy appear to have poor 30-day survival and abysmal 6-month survival.

Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive peripheral T-cell lymphoma typically characterized by prominent lymphadenopathy and B-symptoms at the time of presentation, polyclonal hypergammaglobulinemia, autoimmune hemolysis and frequent but highly variable involvement of Epstein-Barr virus (EBV). Lymph node biopsy findings typically include effacement of nodal architecture, polymorphic infiltrate, atypical T-cells (usually CD4+/CD10+/PD1+) and prominent proliferations of high endothelial venules and follicular dendritic cells. However, this classic constellation of pathologic findings is often initially obscured by a prominence of EBV+ B-immunoblasts with or without associated peripherally circulating EBV DNA. Here we document the first reported case of an acute serologic EBV profile (VCA-IgM) in a patient with AITL, and we recommend that clinicians maintain a high index of suspicion for AITL in the appropriate clinical scenario, irrespective of Epstein-Barr related findings.

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