Brain signal decoding promises significant advances in the development of clinical brain computer interfaces (BCI). In Parkinson’s disease (PD), first bidirectional BCI implants for adaptive deep brain stimulation (DBS) are now available. Brain signal decoding can extend the clinical utility of adaptive DBS but the impact of neural source, computational methods and PD pathophysiology on decoding performance are unknown. This represents an unmet need for the development of future neurotechnology. To address this, we developed an invasive brain-signal decoding approach based on intraoperative sensorimotor electrocorticography (ECoG) and subthalamic LFP to predict grip-force, a representative movement decoding application, in 11 PD patients undergoing DBS. We demonstrate that ECoG is superior to subthalamic LFP for accurate grip-force decoding. Gradient boosted decision trees (XGBOOST) outperformed other model architectures. ECoG based decoding performance negatively correlated with motor impairment, which could be attributed to subthalamic beta bursts in the motor preparation and movement period. This highlights the impact of PD pathophysiology on the neural capacity to encode movement vigor. Finally, we developed a connectomic analysis that could predict grip-force decoding performance of individual ECoG channels across patients by using their connectomic fingerprints. Our study provides a neurophysiological and computational framework for invasive brain signal decoding to aid the development of an individualized precision-medicine approach to intelligent adaptive DBS.
In this paper, we present a novel Deep Neural Network-based indoor localization method that estimates the position of a Bluetooth Low Energy (BLE) transmitter (tag) by using the received signals’ characteristics at multiple Anchor Points (APs). We use the received signal strength indicator (RSSI) value and the in-phase and quadrature-phase (IQ) components of the received BLE signals at a single time instance to simultaneously estimate the angle of arrival (AoA) at all APs. Through supervised learning on simulated data, various machine learning (ML) architectures are trained to perform AoA estimation using varying subsets of anchor points. In the final stage of the system, the estimated AoA values are fed to a positioning engine which uses the least squares (LS) algorithm to estimate the position of the tag. The proposed architectures are trained and rigorously tested on several simulated room scenarios and are shown to achieve a localization accuracy of 70 cm. Moreover, the proposed systems possess generalization capabilities by being robust to modifications in the room’s content or anchors’ configuration. Additionally, some of the proposed architectures have the ability to distribute the computational load over the APs.
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