The aim of this study was to investigate in vitro antioxidant and antimicrobial potential of methanol and chloroform extracts of Sanguisorba minor L. subsp. muricata Briq. herba. Total phenolic and flavonoid content of the investigated extracts were characterized. Antioxidant activity was estimated by five different in vitro assays. Antioxidant potency composite index was calculated also. Antimicrobial activity was tested against nine bacterial and one fungus strains by the micro-well dilution assay. The methanol extract of S. minor contains more phenols and shows the stronger antioxidant and antibacterial activity in comparison to the chloroform extract. However, the chloroform extract was superior to the methanol extract in content of flavonoids. Gram-positive bacteria were more sensitive than Gram-negative, to both extracts, Staphylococcus aureus being the most sensitive. Sanguisorba minor extracts were not considerably active against Candida albi-cans. The previous research data about Sanguisorba minor are scarce, so this data represent the first report on antimicrobial activity of S. minor. These results indicate that extracts of S. minor subsp. muricata have evidence-based potential for more comprehensive studies.
Barjaktarevic et al.: Biological Activities of Salvia verticillata L. Extracts Salvia verticillata L. is a well-known plant from the family Lamiaceae. The purpose of this research was to analyze the cytotoxic, antioxidant and antimicrobial activities of chloroform and petroleum ether root extracts of Salvia verticillata. The total content of phenolic compounds and flavonoids were determined in both of the extracts. The antioxidant activity was estimated in vitro using different assays. The antimicrobial potential was tested against different test strains using micro-well dilution assay. The cytotoxic activity was evaluated on epithelial, human breast cancer cell line MDA-MB-231 and human colorectal carcinoma cell line HCT 116 by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. The extracts showed similar antioxidant activity. The values for the antimicrobial activity differed depending on the microbial strain as well on the solvent used. There were significant differences in cytotoxic effect on investigated cell lines depending of the concentration. Half maximal inhibitory concentration value for chloroform extract was 77.16 μg/ml for MDA-MB-231 cell line and 105.08 μg/ml for the HCT 116 cell line. Half maximal inhibitory concentration value for petroleum ether extract was 30.90 μg/ml for MDA-MB-231 cell line and 44.28 μg/ml for the HCT 116 cell line.
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