Through
PhI(OAc)2-oxidized dearomatization and diesterification
of 3′-hydroxy-[1,1′-biphenyl]-2-carboxylic acids, a
series of polycyclic compounds possessing an altenuene backbone were
obtained in moderate to good yields. The Umpolung diesterification
reaction was completed under mild reaction conditions without an additional
nucleophilic reagent. This work offers a concise method for the synthesis
of diverse natural altenuene analogues. The mechanism was proposed,
and the [1,5]-H shift was studied in isomerization from the ketone-form
structure to a phenol employing computational studies.
A metal-free oxidative decarboxylation reaction of propiolic acids mediated by hypervalent iodine(III) reagents was described. This decarboxylative C–O bond-forming reaction used a combination of (diacetoxyiodo)benzene and aromatic, heteroaromatic or aliphatic...
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