In the present study, we demonstrated the effect of hydrogen bonding in the semiconducting behaviour of a small molecule used in organic field-effect transistors (OFETs). For this study,t he highly soluble dumbbell-shaped molecule, Boc-TATDPP based on aB oc-protected thiophenediketopyrrolopyrrole (DPP) and triazatruxene (TAT)m oieties was used. The two Boc groups of the molecule were removed by annealing at 200 8C, which createdas trong hydrogen-bonded network of NH-TATDPP supported by additional p-p stacking. These were characterised by thermogravimetric analysis (TGA), UV/Vis and IR spectroscopy,X RD and high-resolution (HR)-TEM measurements. FETsw ere fabricat-ed with the semiconducting channel made of Boc-TATDPP and NH-TATDPP separately.I ti sw orth mentioning that the Boc-TATDPP film can be cast from solutiona nd then annealedt og et the other systemsw ithN H-TATDPP.M ore importantly,NH-TATDPP showedsignificantly higherhole mobilities compared to Boc-TATDPP.I nterestingly,t he high hole mobility in the case of NH-TATDPP was unaffectedu pon blendingw ith [6,6]-phenyl-C71-butyrica cid methyl ester (PC 71 BM). Thus, this robust hydrogen-bonded supramolecular network is likely to be useful in designing efficient and stable organico ptoelectronic devices.[**] OFET = organicfield-effect transistor.Supporting information and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.
Investigation of the side-chain impact on optoelectronic and structural properties in new low band-gap dumbbell-shaped molecules with high π-stacking abilities.
Objectives
Multidrug resistance (MDR) remains a primary challenge in breast cancer treatment. In the present study, D‐alpha‐tocopheryl polyethylene glycol 1000 succinate (TPGS)‐coated docetaxel‐loaded liposomes were developed as a novel drug delivery system to reverse MDR and enhance breast cancer therapy compared with the traditional liposomes, DSPE‐mPEG‐coated liposomes (stealth liposomes) and commercial Taxotere®.
Key findings
Liposomes were prepared by thin – film dispersion method. Evaluations were performed using human breast cancer MCF‐7 and resistant MCF‐7/ADR cells. The reversal multidrug‐resistant effect was assessed by P‐gp inhibition assay, cytotoxicity, cellular uptake and apoptosis assay.
Results
The TPGS‐chol‐liposomes were of an appropriate particle size (140.0 ± 6.0 nm), zeta potential (−0.196 ± 0.08 mv), high encapsulation efficiency (99.0 ± 0.9) and favourable in vitro sustained release. The TPGS‐coated liposomes significantly improved cytotoxicity and increased the intracellular accumulation of docetaxel in both types of breast cancer cells. The TPGS‐coated liposomes were confirmed to induce apoptosis via a synergistic effect between docetaxel and TPGS. It was demonstrated that TPGS enhanced the intracellular accumulation of drug by inhibiting overexpressed P‐glycoprotein.
Conclusions
The TPGS‐conjugated liposomes showed significant advantages in vitro compared with the PEG‐conjugated liposomes. The TPGS‐conjugated liposomes could reverse the MDR and enhance breast cancer therapy.
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