Today’s artificial intelligence still faces two major challenges. One is that, in most industries, data exists in the form of isolated islands. The other is the strengthening of data privacy and security. We propose a possible solution to these challenges: secure federated learning. Beyond the federated-learning framework first proposed by Google in 2016, we introduce a comprehensive secure federated-learning framework, which includes horizontal federated learning, vertical federated learning, and federated transfer learning. We provide definitions, architectures, and applications for the federated-learning framework, and provide a comprehensive survey of existing works on this subject. In addition, we propose building data networks among organizations based on federated mechanisms as an effective solution to allowing knowledge to be shared without compromising user privacy.

Present-day federated learning (FL) systems deployed over edge networks have to consistently deal with a large number of workers with high degrees of heterogeneity in data and/or computing capabilities. This diverse set of workers necessitates the development of FL algorithms that allow: (1) flexible worker participation that grants the workers' capability to engage in training at will, (2) varying number of local updates (based on computational resources) at each worker along with asynchronous communication with the server, and (3) heterogeneous data across workers. To address these challenges, in this work, we propose a new paradigm in FL called "Anarchic Federated Learning" (AFL). In stark contrast to conventional FL models, each worker in AFL has complete freedom to choose i) when to participate in FL, and ii) the number of local steps to perform in each round based on its current situation (e.g., battery level, communication channels, privacy concerns). However, AFL also introduces significant challenges in algorithmic design because the server needs to handle the chaotic worker behaviors. Toward this end, we propose two Anarchic FedAvg-like algorithms with two-sided learning rates for both cross-device and cross-silo settings, which are named AFedAvg-TSLR-CD and AFedAvg-TSLR-CS, respectively. For general worker information arrival processes, we show that both algorithms retain the highly desirable linear speedup effect in the new AFL paradigm. Moreover, we show that our AFedAvg-TSLR algorithmic framework can be viewed as a meta-algorithm for AFL in the sense that they can utilize advanced FL algorithms as worker-and/or server-side optimizers to achieve enhanced performance under AFL. We validate the proposed algorithms with extensive experiments on real-world datasets.

Machine learning relies on the availability of a vast amount of data for training. However, in reality, most data are scattered across different organizations and cannot be easily integrated under many legal and practical constraints. In this paper, we introduce a new technique and framework, known as federated transfer learning (FTL), to improve statistical models under a data federation. The federation allows knowledge to be shared without compromising user privacy, and enables complimentary knowledge to be transferred in the network. As a result, a target-domain party can build more flexible and powerful models by leveraging rich labels from a source-domain party. A secure transfer cross validation approach is also proposed to guard the FTL performance under the federation. The framework requires minimal modifications to the existing model structure and provides the same level of accuracy as the nonprivacy-preserving approach. This framework is very flexible and can be effectively adapted to various secure multi-party machine learning tasks.

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The protection of user privacy is an important concern in machine learning, as evidenced by the rolling out of the General Data Protection Regulation (GDPR) in the European Union (EU) in May 2018. The GDPR is designed to give users more control over their personal data, which motivates us to explore machine learning frameworks with data sharing without violating user privacy. To meet this goal, in this paper, we propose a novel lossless privacy-preserving tree-boosting system known as SecureBoost in the setting of federated learning. This federated-learning system allows a learning process to be jointly conducted over multiple parties with partially common user samples but different feature sets, which corresponds to a vertically partitioned virtual data set. An advantage of SecureBoost is that it provides the same level of accuracy as the non privacy-preserving approach while at the same time, reveal no information of each private data provider. We theoretically prove that the SecureBoost framework is as accurate as other non-federated gradient tree-boosting algorithms that bring the data into one place. In addition, along with a proof of security, we discuss what would be required to make the protocols completely secure.

TP53 missense mutations significantly influence the development and progression of various human cancers via their gain of new functions (GOF) through different mechanisms. Here we report a unique mechanism underlying the GOF of p53-R249S (p53-RS), a p53 mutant frequently detected in human hepatocellular carcinoma (HCC) that is highly related to hepatitis B infection and aflatoxin B1. A CDK inhibitor blocks p53-RS's nuclear translocation in HCC, whereas CDK4 interacts with p53-RS in the G1/S phase of the cells, phosphorylates it, and enhances its nuclear localization. This is coupled with binding of a peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) to p53-RS, but not the p53 form with mutations of four serines/threonines previously shown to be crucial for PIN1 binding. As a result, p53-RS interacts with c-Myc and enhances c-Myc-dependent rDNA transcription key for ribosomal biogenesis. These results unveil a CDK4-PIN1-p53-RS-c-Myc pathway as a novel mechanism for the GOF of p53-RS in HCC.

Visual object detection is a computer vision-based artificial intelligence (AI) technique which has many practical applications (e.g., fire hazard monitoring). However, due to privacy concerns and the high cost of transmitting video data, it is highly challenging to build object detection models on centrally stored large training datasets following the current approach. Federated learning (FL) is a promising approach to resolve this challenge. Nevertheless, there currently lacks an easy to use tool to enable computer vision application developers who are not experts in federated learning to conveniently leverage this technology and apply it in their systems. In this paper, we report FedVision - a machine learning engineering platform to support the development of federated learning powered computer vision applications. The platform has been deployed through a collaboration between WeBank and Extreme Vision to help customers develop computer vision-based safety monitoring solutions in smart city applications. Over four months of usage, it has achieved significant efficiency improvement and cost reduction while removing the need to transmit sensitive data for three major corporate customers. To the best of our knowledge, this is the first real application of FL in computer vision-based tasks.

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