Using the ERA5 reanalysis, sea surface temperature and sea ice observations, and the real-time multivariate Madden–Julian index, this study explores a sudden stratospheric warming (SSW) in January 2021, its favorable conditions, and the near surface impact. Wavenumbers 1 and 2 alternately contributed to the total eddy heat flux from mid-December 2020 to late January 2021, and the wavenumber 2 during the onset period nearly split the stratospheric polar vortex. In mid-December 2020 and during the 2021 New Year period (1–5 January 2021), a blocking developed over the Urals, which enhanced the local ridge and the climatological wavenumber 2. Composite results confirm that the Arctic sea ice loss in autumn and La Niña favor the deepening of the high latitude North Pacific low and the increase of the Urals height ridge, which together enhance the planetary waves and hence disturb the stratospheric polar vortex. However, the Madden–Julian oscillation (MJO) in the tropics was dormant in mid-to-late December 2020 and early January 2021, and the well-established statistical relationship between the MJO convection over the western Pacific and the SSW is not applicable to this special case. The cold air outbreak in China during the 2021 New Year period before the January 2021 SSW onset is not explained by the SSW signal which developed in the stratosphere. In contrast, the downward-propagating signal reached the near surface in mid-February 2021, which may contribute to the cold air outbreak in US and may help to explain the extreme coldness of Texas in middle February.
Bone allografts are used to replace bone that has been removed or to augment bone tissue in a number of clinical scenarios. In order to minimize the risk of infection and immune response, the bone is delipidated and terminally sterilized prior to implantation. The optimal method for bone graft sterilization has been the topic of considerable research and debate. Recently, supercritical carbon dioxide (SCCO(2)) treatments have been shown to terminally sterilize bone against a range of bacteria and viruses. This study aimed to evaluate the effect of these SCCO(2) treatments on the anisotropic mechanical properties of cortical bone. Adult bovine cortical cubes were prepared and treated using SCCO(2) and a range of common processing additives (ethanol, peracetic acid and hydrogen peroxide). The bone was mechanically tested in uniaxial compression in the axial, radial and tangential orientations. Ultimate stress, strain, elastic modulus, energy and stiffness were evaluated. This study found that SCCO(2) treatment without additive did not alter the ultimate stress, stiffness or energy to failure depreciably in any orientation. The addition of sterilants peracetic acid and hydrogen peroxide also preserved mechanical function, with no deleterious effect on stress or stiffness. This study highlights the expediency of SCCO(2) treatment for bone allograft processing as terminal sterilization can be achieved while maintaining the intrinsic mechanical properties of the graft.
Background: What is the right surface for an implant to achieve biological fixation? Surface technologies can play important roles in encouraging interactions between the implant surface and the host bone to achieve osseointegration. Preclinical animal models provide important insight into in vivo performance related to bone ongrowth and implant fixation. Methods: A large animal model was used to compare the in vivo response of HA and plasma-sprayed titanium coatings in a well-reported adult ovine model to evaluate bone ongrowth in terms of mechanical properties in cortical sites, and histology and histomorphometry in cortical and cancellous sites at 4 and 12 weeks. Results: Titanium plasma-sprayed surfaces outperformed the HA-coated samples in push-out testing in cortical sites while both surfaces supported new bone ongrowth and remodeling in cortical and cancellous sites. Conclusions: While both HA and Ti plasma provided an osteoconductive surface for bone ongrowth, the Ti plasma provided a more robust bone-implant interface that ideally would be required for load transfer and implant stability in the longer term.
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