Efficient elimination of antibacterial activity of halogenated antibiotics by dehalogenation pretreatment is desired for a biochemical treatment process. In this study, crystalline cobalt phosphide nanosheet arrays on a Ti plate (C-CoP/Ti) are fabricated by a simple electrodeposition and phosphorization process. The crystalline structure greatly promotes atomic hydrogen (H*) generation. Moreover, the nanosheet arrays can provide abundant active sites and accelerate electron transfer and mass transport. As a result, the dehalogenation rate of florfenicol (FLO, an emerging organic pollutant) on C-CoP/Ti is 11.1, 2.97, and 13.6 times higher than that on amorphous CoP/Ti, Pd/Ti, and bare Ti, respectively. The C-CoP/Ti electrode achieves 97.4% dehalogenation of FLO (20 mg L −1 ) within 30 min at −1.2 V (vs Ag/AgCl). Nearly 100% of Cl and 20% of F are broken away within 120 min, showing the highest electrocatalytic defluorination efficiency reported so far. Both experimental results and theoretical calculations reveal that the dehalogenation of FLO on C-CoP/Ti is synergistically accomplished via direct reduction of electron transfer and indirect reduction of H*. This study develops a highly efficient non-noble metal electrode material for dehalogenation of halogenated organic compounds.

O-GlcNAcylation is a ubiquitous post-translational modification of proteins that is involved in the majority of cellular processes and is associated with many diseases. To reduce the workload and increase the relevance of experimental identification of protein O-GlcNAcylation sites, O-GlcNAcPRED, a support vector machine (SVM)-based model, was developed to capture potential O-GlcNAcylation sites. By virtue of the novel adapted normal distribution bi-profile Bayes (ANBPB) feature extraction method, O-GlcNAcPRED yielded a sensitivity of 80.83%, a specificity of 78.17% and an accuracy of 79.50% in jackknife cross-validation experiments. In an independent test on 38 recently experimentally identified human O-GlcNAcylated proteins with 67 O-GlcNAcylation sites, O-GlcNAcPRED captured 26 proteins and 39 sites, clearly outperforming the existing predictors, YinOYang and O-GlcNAcscan.

Purpose The Sophisticated Harmonic Artifact Reduction for Phase data (SHARP) method has been proposed for the removal of background field in MRI phase data. It relies on the spherical mean value (SMV) property of harmonic functions, and its accuracy depends on the radius of the sphere used for computing the SMV and truncation threshold needed for deconvolution. The goal of this work is to develop an alternative SMV based background field removal method with reduced dependences on these parameters. Methods The proposed background field removal method (termed iterative SMV or iSMV) consists of applying the SMV operation repeatedly on the field map and it was validated in a phantom and in vivo brain data of five healthy volunteers. Results The iSMV method demonstrates accurate background field removal in the phantom. Compared to SHARP, the iSMV method shows a significantly reduced dependence on the SMV radius both in phantom and in human data. Because a smaller radius can be chosen, the iSMV method allows retaining a larger part of the region of interest, compared to SHARP. Conclusion The iSMV method is an effective background field removal method with a reduced dependence on method parameters.

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