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ABSTRACT:The growth of the mouse parotid glands during 7 and 35 days of postnatal life was studied by morphometric methods. The mass of the gland, the volume of each morphological compartment, and the cell number in each compartment were evaluated. The data obtained for each evaluated dimension were adjusted by an exponential equation, of the type Y = a.e K.X , thus permitting the calculation of their mean duplication time (T D ), i.e., an estimation of their growth rate. Analysis of the results showed a marked 1,424% increase in the gland mass during the whole studied period, with T D = 7.10 days. This growth occurred by increases in absolute volume of acini, intercalated ducts, striated ducts, excretory ducts and stroma, with percentual increases of 3,048%, 417%, 2,662%, 2,594% and 367%, respectively, and T Ds of 5.62, 11.71, 5.55, 5.47 and 14.45 days, respectively. Analysis of the cell number growth in each compartment showed increases of 1,904%, 285%, 1,228%, 1,090% and 286%, respectively, and T Ds of 6.62, 20.40, 7.19, 7.26 and 14.51 days, respectively. Based on the present results, we concluded that the growth of the mouse parotid glands from day 7 to day 35 of age occurred by intense cell accumulation, mainly in the acini, striated ducts and excretory ducts, with a growth rate sensibly higher than that of the intercalated ducts and stroma. DESCRIPTORS: Parotid gland; Growth and embryonic development; Regression analysis; Histology; Animals. RESUMO:O crescimento das glândulas parótidas do camundongo durante 7 e 35 dias de vida pós-natal foi estudado por métodos morfométricos. A massa glandular, o volume de cada compartimento morfológico e o número de células em cada compartimento foram avaliados. Os dados obtidos para cada dimensão avaliada foram ajustados por equação exponencial, tipo Y = a.e k.x , permitindo o cálculo do seu tempo de duplicação médio (T D ), ou seja, uma estimativa da sua velocidade de crescimento. A análise dos resultados mostrou a ocorrência de um marcante aumento de massa glandular no período estudado de 1.424%, com T D = 7,10 dias. Esse crescimento glandular ocorreu por aumentos nos volumes absolutos dos ácinos, dos ductos intercalares, dos ductos estriados, dos ductos excretores e do estroma, com aumentos percentuais de, respectivamente, 3.048%, 417%, 2.662%, 2.594% e 367%, e T Ds de 5,62, 11,71, 5,55, 5,47 e 14,45 dias. A análise da evolução do número de células em cada compartimento demonstrou aumentos de, respectivamente, 1.904%, 285%, 1.228%, 1.090% e 286% e T Ds de 6,62, 20,40, 7,19, 7,26 e 14,51 dias. Baseados nos resultados aqui obtidos, concluímos que o crescimento das glândulas parótidas do camundongo entre os dias 7 e 35 de idade ocorre por intenso acúmulo de células, principalmente nos ácinos e nos ductos estriados e excretores, com uma velocidade de crescimento sensivelmente maior que nos ductos intercalares e no estroma.

Orthodontic treatment in patients with cleft lip and palate (CLP) is challenging. Alignment of the maxillary segments and orthodontic levelling of the teeth adjacent to the cleft area are important before alveolar bone grafting (ABG), in the permanent dentition. In this clinical report, orthodontic procedures, before and after late ABG, are described as an alternative that can optimise the orthodontic and periodontal results. The gingival margins of the teeth adjacent to the cleft area were levelled. Root divergence was corrected. Interdental papilla and improvement of the periodontal condition were obtained.

Comparison of craniofacial changes after bimaxillary orthognathic surgery in class III individuals with unilateral cleft lip and palate and isolated cleft palateThe aim of this study was to radiographically assess the characteristics and craniofacial changes of patients with unilateral cleft lip and palate undergoing orthognathic surgery for class III correction and to compare the findings with a control group of patients with isolated cleft palate also undergoing orthognathic surgery for Class III correction. The study sample was lateral x-ray radiographs of 45 patients selected retrospectively and randomly, divided into 2 groups: (1) experimental group: 30 adult patients with unilateral cleft lip and palate undergoing bimaxillary orthognathic surgery for correction of class III and (2) control group: 15 adult patients with isolated cleft palate undergoing bimaxillary orthognathic surgery for class III correction.Craniofacial and soft tissue thickness measurements were performed on lateral norm radiographs, preoperatively and 6 months after surgery. The data obtained through cephalometric analysis were compared statistically using the ANOVA test and Pearson's correlation coefficient. The individuals in the experimental group showed a greater vertical increase in the maxilla, less sagittal projection of the subnasal point, a poorer relationship between the lips, greater protrusion, thickness and eversion of the lower lip, in addition to greater thickness of soft tissue in the chin region compared to the control group, at T1 and T2. Even with the corrective effect for occlusion and for the relationship of hard tissues, bimaxillary orthognathic surgery did not allow the same results on soft tissues, which showed a less harmonic conformation in the experimental group.

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We present a case report of early Le Fort I osteotomy with maxillary advancement retained postoperatively by Class III elastics anchored on miniplates in growing patients with complete unilateral cleft lip and palate (UCLP). A 14-year-old boy who underwent orthognathic surgery at the pubertal growth spurt was presented. During surgery, Bollard miniplates were installed in the posterior region of the maxilla and in the anterior region of the mandible. Class III elastics anchored on miniplates were used at night (8–10 h) starting 60 days after surgery. The force of the elastics progressively increased from 100 g to 250 g. The elastics were replaced daily. The positive overjet remained stable over 15 months of postoperative follow-up. Maxillary advancement was adequately retained using Bollard miniplates and the facial profile remained stable until the end of facial growth.

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