Evidence demonstrates the bidirectional communication and regulation between the neuroendocrine and immune systems. Thyroid hormones play key roles in nervous system development and can exert influence on various immune cells contributing to pathophysiological conditions. Octyl methoxycinnamate (OMC) is one of the most commonly used UV filters, and in vitro and in vivo studies have found thyroid disrupting effects. The present study assessed whether OMC administration in mice dams during the lactational period can cause thyroid disruption and generate immunologic alterations in the offspring. Indirect exposure to the OMC (1,000 mg/kg) in the lactational period affected neurodevelopment parameters, such as delayed eye-opening and weight gain in mice of both sexes, and these alterations are corroborated by the decrease in the T4 levels present in the pups' blood. No significant changes were observed in the thymus of these pups, but the number of lymphocytes increased in the spleen of the animals exposed to OMC, similar to the animals treated with propyl-thiouracil (PTU), a well-known thyroid disruptor. OMC modulated the percentage of leukocyte populations in peripheral blood, and the number of circulating polymorphonuclear cells increased twofold. In vitro, OMC exhibited an inhibitory effect on splenocyte proliferation and IL-2 production induced by anti-CD3 antibody; however, this effect was reversed with the addition of T4 in the cell culture. In summary, the results of the present study demonstrate the influence of OMC on thyroid dysregulation and its impact on the modulation of the immune system in mice pups.
Esse artigo buscou avaliar o papel de uma Feira de Ciências como instrumento pedagógico de integração entre educação básica e profissional técnica. A Feira de Ciências se apresenta como um universo rico e atraente nas escolas, à medida que pode atuar possibilitando a integração entre os conteúdos trabalhados nas diferentes disciplinas, abrangendo uma discussão das dimensões política, econômica e social. As etapas do desenvolvimento deste projeto foram descritas e os trabalhos apresentados foram analisados quanto a integração das disciplinas. Os resultados apontaram a Feira de Ciências como uma importante ferramenta de articulação do trabalho pedagógico no interior da escola, fortalecendo a integração de conteúdos e dos processos avaliativos entre as disciplinas, além de proporcionar aos alunos serem protagonistas no processo de ensino-aprendizagem.
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