Background & Aims-5-FU-based adjuvant chemotherapy does not increase survival times of patients with colorectal tumors with microsatellite instability. We determined the response of patients with colorectal tumors with the CpG island methylator phenotype (CIMP) to 5-FU-based therapy.

Background & Aims-Approximately half of the families that fulfill Amsterdam criteria for Lynch syndrome or hereditary non-polyposis colorectal cancer (HNPCC) do not have evidence of the germline mismatch repair (MMR) gene mutations that define this syndrome and result in microsatellite instability. The carcinogenic pathways and the best diagnostic approaches to detect microsatellite stable (MSS) HNPCC tumors are unclear. We investigated the contribution of epigenetic alterations to development of MSS HNPCC tumors.

Climate change has led to the rise of a sustainable development area characterized by the consumers' consideration of social and environmental issues. The existing literature on responsible consumption has essentially explored the context of western countries; however, little information is given around the consumer behavior towards green products in developing countries. This study enriches this literature by exploring the context of Vietnam that was heavily affected by climate changes.More precisely, the authors aim to explore the content of green products from the consumers' point of view, as well as their motivations and barriers to consume ecofriendly products. A qualitative study conducted with 29 Vietnamese respondents showed that consumers associate green products to five dimensions: environment, health, quality, price, and animal welfare. They express essentially egoistic motivations related to health and product's quality. In addition, the main barriers to purchase green products identified in the study correspond to the lack of information and confidence towards green claims, sellers, and certifications.Note. PCE: perceived consumer effectiveness.

In the mainstream of green consumption literature, it is asserted that information on eco-certification, brand, and country-of-origin has certain effects on consumer behavior. This study explores how eco-certification origin and brand origin would interact and influence the consumers’ purchase intent for green products. To achieve this objective, the authors conducted a 2 (eco-certification: domestic vs foreign) × 2 (brand: domestic vs foreign) between-subject experiment with 640 Vietnamese respondents. The results indicate that Vietnamese consumers are more inclined to purchase green products with domestic brands, while eco-certification origin has no main effect on such behavior. Moreover, a moderate incongruity effect between eco-certification origin and brand origin is partially confirmed. These effects are moderated by the product involvement, brand familiarity, product familiarity, and individuals’ demographic characteristics. The authors consequently draw theoretical and managerial implications from the results obtained.

This study explores the motivations for green product consumption in Vietnam-a populous developing country heavily influenced by climate change, under the presence of moderators and mediator variables. A sequential mixed method with two studies was conducted to archive the objectives. Study 1 interviewed 29 Vietnamese consumers to explore their main motivations for green products' purchase intent. These motivations were examined in Study 2 with 682 consumers from 32 provinces and cities in Vietnam. The results conveyed that Vietnamese consumers purchased green products mostly because of health, environment, and quality motivations. Environmental motivation was also a mediator between health and purchase intent. Consumers seemed not concerned about hedonism and social responsibility when considering the purchase. Product category (nonfood green products or organic food), gender, and age did not moderate the motivations' power. However, high-income consumers tended more concern of health, and child presence might enhance the concern for environmental protection. From the findings, the authors draw some implications for the stakeholders in the end.

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