The prosodic characteristics of "motherese" were examined in the speech of 24 German mothers to their newborns. Each subject was recorded in three observational conditions, while addressing (a) her 3-to 5-day-oId baby (M-B Speech); (b) the absent infant, as if present (Simulated M-B Speech); and (c) the adult interviewer (M-A Speech). For each subject, 2-minute speech samples from each condition were acoustically analyzed. It was found that in M-B Speech, mothers spoke with higher pitch, wider pitch excursions, longer pauses, shorter utterances, and more prosodic repetition than in M-A Speech. Furthermore, 77% of the utterances in the M-B Speech sample conformed to a limited set of prosodic patterns that occurred only rarely in adult-directed speech, i.e., they consisted of characteristic "expanded" intonation contours, or they were whispered. The prosody of mothers' speech is discussed in terms of its immediate influence within the context of motherinfant interaction, as well as its potential long-range contribution to perceptual, social, and linguistic development.

No abstract

Treatment with high-dose famotidine significantly reduces the cumulative incidence of both gastric and duodenal ulcers in patients with arthritis receiving long-term NSAID therapy.

No abstract

Background Manipulation under anaesthesia and arthroscopic capsular release are costly and invasive treatments for frozen shoulder, but their effectiveness remains uncertain. We compared these two surgical interventions with early structured physiotherapy plus steroid injection. MethodsIn this multicentre, pragmatic, three-arm, superiority randomised trial, patients referred to secondary care for treatment of primary frozen shoulder were recruited from 35 hospital sites in the UK. Participants were adults (≥18 years) with unilateral frozen shoulder, characterised by restriction of passive external rotation (≥50%) in the affected shoulder. Participants were randomly assigned (2:2:1) to receive manipulation under anaesthesia, arthroscopic capsular release, or early structured physiotherapy. In manipulation under anaesthesia, the surgeon manipulated the affected shoulder to stretch and tear the tight capsule while the participant was under general anaesthesia, supplemented by a steroid injection. Arthroscopic capsular release, also done under general anaesthesia, involved surgically dividing the contracted anterior capsule in the rotator interval, followed by manipulation, with optional steroid injection. Both forms of surgery were followed by postprocedural physiotherapy. Early structured physiotherapy involved mobilisation techniques and a graduated home exercise programme supplemented by a steroid injection. Both early structured physiotherapy and postprocedural physiotherapy involved 12 sessions during up to 12 weeks. The primary outcome was the Oxford Shoulder Score (OSS; 0-48) at 12 months after randomisation, analysed by initial randomisation group. We sought a target difference of 5 OSS points between physiotherapy and either form of surgery, or 4 points between manipulation and capsular release. The trial registration is ISRCTN48804508.