To evaluate the effect of bioactive peptide (P) in combination with high level of zinc (HZ) or acidifiers on growth performance, complete blood cell counts (CBC) and nutrient digestibility in nursery pigs, a total of 288 weaned pigs (PIC1050xDNA600) were stratified by initial BW within gender and allotted to 1of 7 treatments. Treatments for phase 1&2 were: 1) nutrient adequate positive control with HZ (PC), 2) nutrient deficient negative control with HZ (NC, -0.13% SID Lysine by reducing fish meal), 3) NC+0.25% peptide (0.25PZ), 4) NC+0.5% peptide (0.5PZ), 5) NC+0.25% peptide with standard zinc (0.25P), 6) NC+0.5% peptide with standard zinc (0.5P), 7) as 5 + 0.1% sodium butyrate and 0.5% benzoic acid (PSB). All pigs were fed a common low Zn diet (197 ppm) during phase 3. The whole blood was obtained from a close-to-average pen-BW pig repeatedly at weaning, and at the end of phase 2 and 3 to determine CBC. Titanium dioxide was used as an indigestible marker to determine nutrient digestibility. Data were analyzed using the Mixed procedures of SAS as a RCBD with treatment as fixed effect, and BW block as random effect. In overall phase 1&2, pigs fed PSB had similar ADG and BW when compared to pigs fed 0.25PZ and both were greater than NC pigs (Table 1). With the same inclusion rate of peptide, pigs fed a high zinc diet had greater BW and ADG than pigs fed a standard zinc diet. PSB pigs had the greatest G:F ratio and nitrogen digestibility among treatments. Increasing peptide in high zinc diets gradually decreased Neutrophil-to-lymphocyte ratio. This study indicates that the improvement in growth performance from pigs fed peptide is pharmaceutical zinc dependent and acidifiers can be an alternative to replace ZnO without affecting growth performance.
A 42-d commercial nursery study was conducted utilizing 1,296 pigs (DNA genetics, BW: 5.27 ± 0.05 kg; 21-d of age) that evaluated the efficacy of replacing animal protein products while also reducing SID Lys in nursery pig diets with a bioactive peptide-based feed additive program on growth performance, efficiency, health and well-being, and profitability. The dietary treatments were applied over 3 phases (PH) and were fed based on a feed budget: PH1: 2.27 kg/pig [Positive Control (PC): 1.46% SID Lys; 3,415 kcal/kg ME]; PH2: 4.54 kg/pig (PC: 1.42% SID Lys; 3,395 kcal/kg ME); and PH3: 15.88 kg/pig (1.26% SID Lys; 3,395 kcal/kg ME). The four dietary treatments were: 1) PC: complex diet in PH1-2 and standard diet in PH3; 2) negative control (NC): diet in PH1-2 devoid of fishmeal and spray-dried plasma and -0.10% SID Lys compared to the PC and PH3 the same as the PC; 3) PEP1 in PH1-2 was the NC diets plus Peptiva® Maximo (Vitech Bio-Chem Corp., Orange, CA) fed at 0.25% and in PH3 the PC + Peptiva® Optimo fed at 0.1%; 4) PEP2 in PH1-2 was the NC diets plus Peptiva® Maximo fed at 0.50% and in PH3 the PC plus Peptiva® Optimo fed at 0.2%. Pen weights of pigs and pen feed consumption were evaluated in 2-wk increments and overall. Additionally, animal health and well-being and economics were evaluated for the entire nursery program. Overall, pigs fed the PEP1 diets had a better FCR (with or without mortality adjustments) than either control group, while the PEP2 group was intermediate. These results indicate that highly digestible proteins, such as fish meal and spray-dried plasma, can be removed from early nursery diets while supplementing with bioactive-peptide feed additive strategy to optimize performance and economics of production.
At 8-wk post-weaning, pens of split-sexed pigs (26.0 ± 0.25 pigs/pen; 31.3 ± 0.11 kg; DNA genetics) being housed in a commercial research unit were randomly assigned to one of two dietary treatments to compare the growth performance and efficiency of the system’s commercial nutritional program that included narasin (Skycis™, Elanco Animal Health, Greenfield, IN) at 13.6 g/tonne to a product (2 kg/tonne) containing a combination of bioactive peptides and enzymes (PEP; Peptiva® Optimo, Vitech Bio-Chem Corporation, Orange, CA). Dietary treatments were fed through 4 phases based on feed budgets. Pens were weighed bi-weekly through 59-d on test. There were 12 replications or pens per treatment. Feed was delivered and measured using a Feed Logic system and weigh backs were conducted utilizing a calibrated ruler. Average daily gain and feed intake were calculated on a pen basis. Data were analyzed as a mixed model with dietary treatment, gender, and treatment x gender interaction included. There were no interactions reported (P ≥ 0.0965). During the study pigs performed at or above their commercial counterparts. Overall, body weight, ADG, and ADFI were not impacted by treatment, but pigs fed PEP had an 2.1% improvement in feed efficiency compared to the narasin fed pigs. These results indicate that feeding bioactive peptides plus enzymes may improve feed efficiency without the need of an ionophore in the grower period in a commercial swine facility.
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