Irradiating intense femtosecond laser pulses on a glass sample containing silver nanoparticles results in permanent sample color changes if the laser wavelength is in the region of the particles’ surface plasmon resonance. In particular, even a single pulse of appropriate intensity can modify the initially isotropic extinction of glass containing spherical particles to a dichroic sample behavior in the irradiated area. This observation is interpreted as ultrafast particle deformation induced by the laser pulse creating nonspherical particles of uniform orientation.

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Radiotherapy is widely accepted as primary treatment in the T1 stage of glottic cancer, but controversy surrounds the proper approach to T2 lesions of the glottis. A retrospective review of 90 patients addresses treatment results for T1 and T2 lesions of glottic carcinoma managed by primary radiotherapy with 60 to 64 Gy from 1977 to 1989. Seventy-nine patients met the criteria for local control analysis with a minimum follow-up of 5 years. Radiotherapy alone controlled disease in 93% (43 of 46) of patients with T1 lesion and 18% (6 of 33) of those with T2 tumors (including 10 patients in whom radiotherapy was terminated at 40 Gy because of persistent tumor). Ultimate control of disease for T1 and T2 lesions, including surgical salvage, was 100% and 82%, respectively. Larynx preservation was achieved in 100% of T1 and in 45% of T2 lesions. Extension of tumor and impaired vocal cord mobility showed statistical significance for adverse prognosis (p < .001). This paper discusses how these results affect treatment of glottic carcinoma, particularly in the T2 stage.