Such or similar scenarios are likely to explain the lack of correlation between baseline or post-therapy circulating monocyte or granulocyte counts and response, and also the lack of correlation between the ratio of post-versus pretherapy cell count and response. Indirect evidence for the importance of intratumoral levels of effector cells is illustrated in the finding by Canioni et al 7 that rituximab is able to circumvent the unfavorable outcome of patients with follicular lymphoma with high amounts of intratumoral macrophages. It might also be interesting to speculate that the patients most likely to benefit from GM-CSF in combination with rituximab may be those who demonstrate considerable accumulation of granulocytes and/or monocytes at their tumor sites before treatment or after a single test dose of GM-CSF, emphasizing the potential usefulness of effector-cell imaging in this setting.
Serial determinations of red cell volumes were made with an electronic sizing device in 30 patients with hepatic cirrhosis. Variations in red cell volumes were correlated with other hematologic and clinical findings. The results of these studies suggest that volume macrocytosis in patients with alcoholic cirrhosis is either due to megaloblastosis of the bone marrow or to an accelerated influx of young red cells into the peripheral blood.
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