Polarization sensitive optical coherence tomography (PS-OCT) is a functional extension of OCT. In addition to imaging based on tissue reflectivity, PS-OCT also enables depth-resolved mapping of sample polarization properties such as phase-retardation, birefringent axis orientation, Stokes vectors, and degree of polarization uniformity (DOPU). In this study, PS-OCT was used to investigate the polarization properties of melanin. In-vitro measurements in samples with varying melanin concentrations revealed polarization scrambling, i.e. depolarization of backscattered light. Polarization scrambling in the PS-OCT images was more pronounced for higher melanin concentrations and correlated with the concentration of the melanin granules in the phantoms. Moreover, in-vivo PS-OCT was performed in the retinas of normal subjects and individuals with albinism. Unlike in the normal eye, polarization scrambling in the retinal pigment epithelium (RPE) was less pronounced or even not observable in PS-OCT images of albinos. These results indicate that the depolarizing appearance of pigmented structures like, for instance, the RPE is likely to be caused by the melanin granules contained in these cells.
Solar-driven
water generation is a sustainable water treatment
technology, helping to relieve global water scarcity issues. However,
this technology faces great challenges due to the high energy consumption
of water evaporation yielding low evaporation rates. Here, a covalent
organic framework (COF)/graphene dual-region hydrogel, containing
hydrophilic and hydrophobic regions in one material, is developed
through a facile in situ growth strategy. The hydrophilic
COF is covering parts of the hydrophobic graphene regions. Through
accurate control of both wetting regions, the hybrid hydrogel shows
effective light-harvesting, tunable wettability, optimized water content,
and lowered energy demand for water vaporization. Acting as solar
absorber, the dual-region hydrogel exhibits a steam generation rate
as high as 3.69 kg m–2 h–1 under
1 sun irradiation (1 kW m–2), which competes well
with other state-of-the-art materials. Furthermore, this hydrogel
evaporator can be used to produce drinkable water from seawater and
sewage, demonstrating the potential for water treatment.
Polycrystalline CoFe2O4 was produced by a ceramic method. The heat-treated powder was pressed, varying the hydrostatic pressure between 87 and 278 MPa, and was heat-treated again at 1350 °C for 24 h. All magnetic parameters showed a clear dependence on this hydrostatic pressure. The saturation magnetization showed a minimum, and the coercivity, the anisotropy, and the magnetostriction showed a maximum at compaction pressures around 150 MPa. This pressure dependence of the magnetic parameters can be explained by a cation redistribution due to the hydrostatic pressure and heat treatment. Additionally, all samples were field-annealed in an external field of 10 T (at 300 °C for 3 h). The field-annealing process causes an induced uniaxial anisotropy, which results in a reduction of the coercivity (in the easy axis) as well as a dramatic increase in the magnitude of the magnetostriction along the hard axis. Maximum magnetostriction value of -400×10-6 was obtained. Additionally, dλ/dH is increased within a factor of three with magnetic heat treatment.
In this contribution, a low-pressure/low-temperature casting technique for the preparation of novel free-standing macrocellular polymer-derived ceramic support structures is presented. Preceramic polymers (polycarbosilane and poly(vinyl)silazane) are combined with sacrificial porogens (ultra-high molecular weight polyethylene microbeads) to yield porous ceramic materials in the Si—C or Si—C—N systems, exhibiting well-defined pore structures after thermal conversion.The planar-disc-type specimens were found to exhibit biaxial flexural strengths of up to 60 MPa. In combination with their observed permeability characteristics, the prepared structures were found to be suitable for potential applications in filtration, catalysis, or membrane science.
Previous studies for melanin visualization in the retinal pigment epithelium (RPE) have exploited either its absorption properties (using photoacoustic tomography or photothermal optical coherence tomography [OCT]) or its depolarization properties (using polarization sensitive OCT). However, these methods are only suitable when the melanin concentration is sufficiently high. In this work, we present the concept of hyperspectral OCT for melanin visualization in the RPE when the concentration is low. Based on white light OCT, a hyperspectral stack of 27 wavelengths (440‐700 nm) was created in post‐processing for each depth‐resolved image. Owing to the size and shape of the melanin granules in the RPE, the variations in backscattering coefficient as a function of wavelength could be identified—a result which is to be expected from Mie theory. This effect was successfully identified both in eumelanin‐containing phantoms and in vivo in the low‐concentration Brown Norway rat RPE.
Due to the high level of light absorption and light scattering of dark colored powders connected with the high refractive indices of ceramic particles, the majority of ceramics studied via stereolithography (SLA) have been light in color, including ceramics such as alumina, zirconia and tricalcium phosphate. This article focuses on a lithography-based ceramic manufacturing (LCM) method for β-SiAlON ceramics that are derived from silicon nitride and have excellent material properties for high temperature applications. This study demonstrates the general feasibility of manufacturing of silicon nitride-based ceramic parts by LCM for the first time and combines the advantages of SLA, such as the achievable complexity and low surface roughness (Ra = 0.50 µm), with the typical properties of conventionally manufactured silicon nitride-based ceramics, such as high relative density (99.8%), biaxial strength (σf = 764 MPa), and hardness (HV10 = 1500).
Optical coherence tomography (OCT) is a powerful technology for rapid volumetric imaging in biomedicine. The bright field imaging approach of conventional OCT systems is based on the detection of directly backscattered light, thereby waiving the wealth of information contained in the angular scattering distribution. Here we demonstrate that the unique features of few-mode fibers (FMF) enable simultaneous bright and dark field (BRAD) imaging for OCT. As backscattered light is picked up by the different modes of a FMF depending upon the angular scattering pattern, we obtain access to the directional scattering signatures of different tissues by decoupling illumination and detection paths. We exploit the distinct modal propagation properties of the FMF in concert with the long coherence lengths provided by modern wavelength-swept lasers to achieve multiplexing of the different modal responses into a combined OCT tomogram. We demonstrate BRAD sensing for distinguishing differently sized microparticles and showcase the performance of BRAD-OCT imaging with enhanced contrast for ex vivo tumorous tissue in glioblastoma and neuritic plaques in Alzheimer’s disease.
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