Calcium-dependent release of vasoactive gliotransmitters is widely assumed to trigger vasodilation associated with rapid increases in neuronal activity. Inconsistent with this hypothesis, intact stimulus-induced vasodilation was observed in inositol 1,4,5-triphosphate (IP3) type-2 receptor (R2) knockout (KO) mice, in which the primary mechanism of astrocytic calcium increase – the release of calcium from intracellular stores following activation of an IP3-dependent pathway – is lacking. Further, our results in wild type (WT) mice indicate that in vivo onset of astrocytic calcium increase in response to sensory stimulus could be considerably delayed relative to the simultaneously measured onset of arteriolar dilation. Delayed calcium increases in WT mice were observed in both astrocytic cell bodies and perivascular endfeet. Thus, astrocytes may not play a role in the initiation of blood flow response, at least not via calcium-dependent mechanisms. Moreover, an increase in astrocytic intracellular calcium was not required for normal vasodilation in the IP3R2-KO animals.
Long-period magnetotelluric (MT) data can be used to interpret upper mantle temperature, hydrogen content, and the presence of partial melt, all of which strongly influence mantle viscosity. We have collected the first long-period MT data in Svalbard and have combined them with preexisting broadband MT data to produce a model of the electrical resistivity of Svalbard's upper mantle. Asthenospheric resistivities are low compared to stable continental settings but more comparable to young oceanic asthenosphere, suggesting that the physical state of Svalbard's upper mantle is controlled by its proximity to the Mid-Atlantic Ridge. Interpretation of the MT model using a petrologically constrained genetic algorithm approach shows that partial melt is present in the uppermost asthenosphere beneath Svalbard. This is the first direct evidence of partial melt in Svalbard's asthenosphere from deep geophysical soundings. Viscosities calculated from the geophysical data show a low viscosity layer (~10 18 Pa s) coincident with the partial melt layer, underlain by a higher viscosity layer (~10 20 Pa s) extending to the transition zone. Viscosities calculated from glacial isostatic adjustment (GIA) data in Svalbard show a considerable range due mainly to uncertainties in past ice sheet models. Improved constraints on Svalbard's mantle viscosity from geophysical data may help to improve these GIA models.
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