The major capsaicinoids responsible for pungency in capsicum oleoresins were separated and quantified in an oleoresin model system and in a pharmaceutical model system using HPLC. An analogue of capsaicin, dimethoxybenzylmethyloctamide (DMBMO), was synthesized for use as an internal standard and used for quantification of capsaicin, nordihydrocapsaicin, and dihydrocapsaicin. This novel internal standard has a retention time between that of capsaicin and dihydrocapsaicin and is nonpungent. A precollaborative test was used to check the robustness of the procedure for variations in instrumentation and sample preparation. Changes in sample media were not shown to affect the results.
A series of branched amino polythiaether multidentate ligands has been synthesized involving one or two tertiary amine nitrogen donor atoms to which are appended alkyl chains containing thiaether sulfur donors. The resulting compounds are analogous to the amino polycarboxylate reagents EDTA and NTA. Ligand protonation constants, Cu(II) complex stability constants, and Cu(II) complex formation rate constants have been determined for three
Rainbow trout (Oncorhynchus mykiss) were fed diets supplemented with canthaxanthin, oleoresin paprika and ␣-tocopherol. Canthaxanthin was more efficiently absorbed (3.8-7.9 mg/kg) in the flesh of rainbow trout than the paprika carotenoids (2.4-3.1 mg/kg). With increased pigmentation, decrease in lightness (L * ) and hue angle, and increase in redness (a * ) of the muscle were observed. Canthaxanthin produced more desirable reddish-pink color. Deposition of ␣-tocopherol in liver and muscle tissue increased with increase in dietary ␣-tocopheryl acetate. Fish receiving lower ␣-tocopheryl acetate reached maximum deposition levels earlier than those fed higher levels. There was no effect of ␣-tocopherol and carotenoid levels on muscle fatty acid composition.
ChemInform Abstract ((I) over the pH range 1-5.5; enhanced stability of the Cu complexes in the presence of ClO4-anions due to the decrease of the dissociation rate constants; the effect of hydroxy substituents are attributed to a combination of steric and solvation effects).
Different pharmaceutical preparations against the common cold contain acetaminophen, phenylephrine hydrochloride, and chlorpheniramine maleate. A degradation product had been discovered in these preparations after short- and long-term stability studies. This degradation product was isolated and found to be an adduct of phenylephrine and maleic acid. An account of the isolation and characterization of this compound was published. Our interest in this area led us to synthesize the compound, and we found that the synthesized compound does not have the same spectroscopic properties described in the original paper. Our subsequent work identified the structure of the degradation product as a "Michael addition" product of phenylephrine and maleic acid.
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