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Incidents of mass murder have gained considerable media attention, but are not well understood in behavioral sciences. Current definitions are weak, and may include politically or ideological motivated phenomenon. Our current understanding of the phenomenon indicates these incidents are not peculiar to only western cultures, and appear to be increasing. Methods most prominently used include firearms by males who have experienced challenging setbacks in important social, familial and vocational domains. There often appears to be important autogenic components (Mullen Behavioral Sciences and the Law (22)3, 2004), including dysthymic reactions and similar antecedents. There have been observations of possible seasonal variations in mass murders, but research to date is inadequate to establish this relationship. It is recommended behavioral sciences and mental health researchers increase research efforts on understanding mass killings, as the current socioeconomic climate may increase vulnerability to this phenomenon, and the incidents are not well understood despite their notoriety.

Most studies that have focused on female serial killers (FSKs), although informative, have examined limited sample sizes. We consulted mass media reports of demographics, motives, methods, mental health, and victim characteristics of 64 FSKs who committed their crimes in the US from 1821 to 2008. Consistent with other studies, our data showed that FSKs were typically White, educated, have been married, and held a caregiving role (e.g. mother, health care worker). Nearly 40% of FSKs in this sample experienced some form of mental illness. Their most common motive for murder was financial gain, and their most common method of killing was poisoning. FSKs knew all or most of their victims, and most were related to their victims. In all cases, FSKs targeted at least one victim who was a child, elderly, or infirm -those who had little chance of fighting back. We interpret these killers' behaviors from clinical and evolutionary angles.

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Random controlled trials on the efficacy of naltrexone and acamprosate in the treatment of alcohol dependence were reviewed, using a Relative Benefit (RB) analysis approach. A total of 42 studies were included, showing acamprosate use demonstrated a modest improvement, with a RB of 1.76 at three month follow-up. Short-term administration of naltrexone significantly reduced the relapse rate, but was not associated with modification in the abstinence rate. There was insufficient data available to ascertain the efficacy of naltrexone and acamprosate over prolonged periods of time, or the effectiveness of the medications relative to each other.