The synthesis of biaryl compounds from aryldiazonium salts and arylboronic acids was achieved using PPh3AuCl as catalyst, CsF as base and acetonitrile as solvent. Combined to photosensitizers, irradiation by blue LEDs allowed accelerating the reaction and expanding its scope. Various functional groups were compatible including bromoaryls, iodoaryls, aldehydes and alcohols. A 2-iodobenzyl alcohol moiety was smoothly introduced by this method, enabling its consecutive isotopic labelling by a Pd-catalysed alkoxycarbonylation.

The copper(I)-catalyzed azide alkyne cycloaddition (CuAAC) using the conventional Sharpless-Fokin catalyst that consists of CuSO 4 + Na ascorbate, the most well-known and used "click" reaction, is considerably accelerated by the addition of a tris(triazolyl)-polyethylene glycol (tris-trz-PEG) amphiphilic ligand in water under ambient conditions. Only parts-per-million Cu I were necessary to reach quantitative yields with TON up to 86000 and TOF 3600 h -1 . The ligand was fully recycled, and the catalyst reused at least 6 times without decomposition. Large-scale syntheses were also successfully achieved with 93 % yield. The catalyst was applied to the efficient synthesis of various useful functional products with medicinal, catalytic, targeting, and labeling properties.