The human promyelocytic leukemia cell line HL-60 overexpresses the c-myc protooncogene. A calculated secondary structure for c-myc mRNA placed the initiation codon in a bulge of a weakly base-paired region. Treatment of HL-60 cells with 5' d(AACGTTGAGGGGCAT) 3', complementary to the initiation codon and the next four codons of c-myc mRNA, inhibited c-myc protein expression in a dosedependent manner. However, treatment of HL-60 cells with 5'
• Interventions that involve collaboration among patients, physicians, and/or pharmacists have been significantly associated with improvements in medication adherence, persistence, and attainment of clinical goals for specific disease states, as well as reductions in the number of medications or the number of highrisk drugs or drug combinations in a patient's regimen. • The 2009 National Committee for Quality Assurance physician metric for medication review among older adults specifies that "counseling about medication" be performed but does not provide guidance about how counseling should be performed, and no clear consensus has emerged regarding the best tools and methods for conducting reviews.
What is already known about this subject
Results from a Mailed Promotion of Medication Reviews Among Department of Defense BeneficiariesReceiving 10 ABSTRACT BACKGROUND: Like many payers, the Department of Defense (DoD) has limited ability to work directly with prescribers to ensure appropriate medication use. Many older beneficiaries are prescribed multiple maintenance medications, placing them at higher risk for adverse drug interactions, contraindicated medication use, and other polypharmacy-related problems. Medication reviews may mitigate these risks, but the optimal venue for medication therapy management is unclear.
The MHS experienced a significant increase in LLT among patients at greatest risk for cardiovascular disease. However, treatment may still be underutilized as approximately one-third of high-risk patients did not receive lipid-lowering medication.
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