The current study aimed at finding the relationship between infection of intestinal parasites and some hematological (complete blood count) and immunological parameters (histamine, interleukin-5, and IgE) in children visiting and infertile at Karbala Children's Hospital in Kerbala, Iraq. Two thousand and five hundred and forty-one fecessamples examined using both direct smear and flotation methods using a saturated salt solution for children aged 1 to 15 for the period from December 2017 to November 2018.The results showed that the total infection percentage of intestinal parasites was 18.93%. Five species of intestinal parasites recorder: Entamoebahistolytica (14.60%), Giardia lamblia (3.90%), Trichomonas hominis (0.16%), Hymenolepis nana (0.59%) and Enterobius vermicularis (0.08%). The percentage of infection inmale was higher than that of females and the percentage of intestinal parasitic infection fluctuated during the study period. The incidence of infection in the age groups of infected children also affected. The statistical analysis showed significant differences (P< 0.05) between the percentage of intestinal parasitic infection with sex and age of children as well as study months and species of parasites recorded.To conduct the hematological and immunological study, 59 infected children selected (30 males, 29 females) and 31 non-infected children (20 males and 11 females). The blood and serumsof these children obtained and examined by a blood analyzer for the hematological parameters and ELIZA method for immunological parameters.