Purpose Angiopoietin-Like3 is a protein that plays an important role in regulating plasma triglyceride concentrations by inhibiting the enzyme lipoprotein lipase. Lipid metabolism and glucose metabolism are closely related and interact with each other. ANGPTL3 may also be a factor involved in blood glucose regulation through an increase in free fatty acids generated from enhanced lipolysis in adipose tissue leading to insulin resistance. This study aimed to investigate plasma ANGPTL3 concentrations and their correlation with lipid and glucose metabolic markers in newly diagnosed type 2 Diabetes Mellitus patients. Subject and Methods A cross-sectional descriptive study was conducted on 98 healthy subjects (control group) and 103 patients with type 2 diabetes at the first diagnosis, without any treatment (patient group). Plasma ANGPTL3 concentration was quantified by the ELISA method. The study determines the correlation of ANGPTL3 concentration with some indicators reflecting lipid and glucose metabolism. Results The concentration of ANGPTL3 in the newly diagnosed type 2 Diabetes Mellitus patient group was lower than in the control group, the difference was statistically significant with p < 0.05. In the patient group: there was an inverse correlation between ANGPTL3 concentration and HDL-C concentration (r = −0.37; p<0.001), and a positive correlation with triglyceride concentration (r = 0.275; p < 0.05). There was no correlation between plasma ANGPTL3 levels and anthropometric indices, total cholesterol, HDL-C, glucose, HbA1C, insulin, and HOMA-IR. In the control group: there was no correlation between ANGPTL3 and any of the indicators mentioned above. Conclusion ANGPTL3 levels in newly diagnosed type 2 diabetes mellitus patients were statistically significantly lower than in healthy subjects. Plasma ANGPTL3 was positively correlated with triglyceride levels and inversely correlated with HDL-C levels in newly diagnosed type 2 Diabetes mellitus patients.
Introduction: Osteoporosis is a common disease that affects many women in the postmenopausal period. Dual-energy X-ray absorptiometry (DXA) is a simple and noninvasive method used to diagnose osteoporosis. The Osteoporosis Self-Assessment Tool for Asians (OSTA) is an osteoporosis risk assessment toolkit, used for menopausal women in Asia. This study aimed to evaluate the diagnostic values of the OSTA index in determining the risk of osteoporosis in postmenopausal women. Material and Methods: This cross-sectional study was conducted on 919 postmenopausal women to determine the value of OSTA in osteoporosis risk assessment. The bone density was measured using the DXA method in the lumbar spine and femoral neck. Results: Based on the ROC curve, the sensitivity and specitivity of OSTA were 70.3% and 63.6% at the cut-off of ≤ -1.4 at the femoral neck or lumber spine or both (p = 0.005) . At a cut-off point of ≤-1 at one of two position or both, the OSTA index showed a specificity of 87.23%, sensitivity of 66.08%, positive predictive value of 46.90%, and negative predictive value of 93.78% in predicting the osteoporosis risk. Conclusions: The OSTA index is a simple tool that is highly sensitive and specific in predicting the risk of osteoporosis in postmenopausal women.
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